JUN 02, 2021 8:00 AM PDT

Exploiting digital histology approaches to probe the pathophysiology of SARS-CoV-2 infection

Sponsored by: Leica Biosystems
C.E. Credits: P.A.C.E. CE Florida CE
Speakers

Abstract
Date:  June 2, 2021
Time: 8:00am (PDT),  11:00am (EDT)
 
COVID-19 is a complex multi-phase disease. In most people an early innate immune response transitions into a broadly effective adaptive immune response that controls the virus. However, 20-30% of symptomatic patients require hospitalisation, with ICU admission rates ranging from 4.9-11.5%, and overall fatality rates of around 0.5%. Long-term inflammation in patients receiving supportive care in ICU can lead to pulmonary fibrosis, representing a third phase of the disease.
 
The success of broad-acting immunosupressants such as dexamethasome clearly demonstrates that while the immune system is involved in disease amelioration it also causes disease exacerbation. Understanding what factors underpin the transition between each phase in the lungs, the site of primary infection, and other organs is required for full understanding of the pathophysiology of SARSCoV-2. Through various researches, our ultimate goal is to inform the optimal selection and scheduling of therapeutic approaches. To achieve this we have undertaken a wide ranging analysis of post-mortem samples from patients at the different stages of COVID-19 disease. Selected results will be presented during the talk.
 
The talk will also cover a range of digital pathology and tissue multiplexing techniques, discuss differences in capabilities of specific research platforms and how they can be effectively combined to probe the biology of the tissue microenvironment.
 
Learning Objectives
  • Describe different techniques involved in molecular histology and how they integrate in a workflow.
  • Identify the pathophysiology of SARS-CoV2 infection in tissues, including related to viral replication and anti-viral immunity.
  • Demonstrate how digital image analyses (immunofluorescence, transcriptomic) can be utilised to determine features of microenvironmental immunity.
 
For Research Use Only. Not for Use in Diagnostic Procedures
 
Webinars will be available for unlimited on-demand viewing after live event.
 
LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

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