NOV 13, 2018 9:00 AM PST

Extracellular Vesicles as Diagnostic and Therapeutic Tools for Cancer

Speaker
  • Ph.D. Student in Technology for Health
    Biography
      Sara Busatto is a Ph.D. student in Prof. Bergese's Colloidal Clinical Chemistry Laboratory at the University of Brescia in Italy. Currently, she is also a visiting pre-doctoral student in Prof. Wolfram's Nanomedicine and Extracellular Vesicles group at Mayo Clinic in Florida (United States). In 2015, Sara graduated from the University of Brescia in Italy with a master's degree in medical biotechnology. Her research focuses on exploring the targeting and drug delivery capacity of extracellular vesicles (EVs) in vitro and in vivo. She has several publications in the field of extracellular vesicles. Busatto's current research project involves studying the interface between EVs and biological membranes, especially focusing on the blood brain barrier. Her goal is to foster and contribute to the progress of personalized and biocompatible nanomedicine, translatable into more effective therapies for the treatment of life-threatening diseases.

    Abstract
    DATE: November 13, 2018
    TIME: 9:00am PST, 12:00pm EST

    Extracellular vesicles (EVs) are cell-secreted nanoparticles that play a pivotal role in intercellular communication that affects both physiological and pathological processes. Therefore, EVs have great potential for diagnostic and therapeutic applications for cancer. EVs can be isolated from cell culture media and patient-derived biological fluids, and exploited as biomarkers or delivery vehicles. In this project, the uptake of EVs in various cancer cells has been evaluated. Moreover, EV RNA profiling has been used as a biomarker of various liver cancer cell lines. Additionally, EVs isolated from cancer cells have been projected into a 2D supported lipid bilayer as the initial step to develop a first of its kind EV biosensor. Taken together, cancer cell derived EVs have great potential for improving the diagnosis and treatment of this disease.
     
    Learning Objectives:
     
    • Understand basic extracellular vesicle concepts: biogenesis, function and future applications
    • Become familiar with extracellular vesicles isolation techniques
    • Explore the role of extracellular vesicles for cancer research: biomarkers, biosensors, and drug delivery vehicles

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