MAY 04, 2016 05:00 AM PDT

Complete workflow solution from gene-to-protein

  • Global Product Manager, Thermo Fisher Scientific
      Dr. Spring is global Product Manager in the SynBio section at Thermo Fisher Scientific, GeneArt in Germany. Michael received his PhD from the University of Göttingen, Germany. After his research work in the HIV field, he joined Micromet, now part of Amgen in Munich as scientist in the pre-clinical development of bi-specific scFv antibodies against cancer and inflammatory diseases. In 2003 he joined GeneArt and worked as senior scientist heading a manufacturing group before switching to Product Management. As PM he is currently responsible for the protein expression & purification and directed evolution services offered to customers in case outsourcing is desired instead of purchasing reagents and do-it-yourself.

    Reliability from gene sequence to the expressed and purified protein is essential for many aspects of basic research and drug development. Thermo Fisher Scientific’s complete portfolio from GeneArt™ gene synthesis to advanced expression systems provides researchers the unique ability to optimize their gene expression results. Our proprietary sequence optimization GeneOptimizer™ improve the sequence via a parallel multi-parameter approach. To further maximize the protein yield, you can chose between our best-in-class serum free expression host systems FreeStyle™ or Expi293™ and ExpiCHO™. Offering reagents for in-house work or a convenient and total service solution, this is the most efficient way to streamline your gene-to-protein workflow for maximal performance. The basis of gene synthesis and optimization will be explained and how the combination with best expression system generates expression reliability and protein yields.

    Learning Objectives:
    • Understand that the combination of gene optimization and best-in-class mammalian expression systems results in increased protein expression & reliability
    • Understand Thermo Fisher / Geneart is the best partner to outsource the complete workflow from expression plasmid generation to purified protein

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