Sr. Director, Protein Business Unit, R&D Systems
BIOGRAPHY
OCT 10, 2019 9:00 AM PDT
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Next Generation Targets for Immuno-Oncology
Presented at:
Cancer Research & Oncology 2019
Speaker
Abstract
Blockade of CTLA-4 and PD-1, members of the B7/CD28 family, have proven to be the most successful cancer immunotherapies to date. While the current therapeutic focus remains on B7/CD28 family members, novel immunoregulatory pathways are being uncovered as potential targets for oncology research and cancer immunotherapy. In this presentation, we discuss some of the next generation of novel immune checkpoint molecules, including Butyrophilins (BTNs), leukocyte immunoglobulin-like receptors (LILRs), and V-Set and Immunoglobulin domain containing (VSIGs). Specifically, we will present data demonstrating that bioactive recombinant Butyrophilin proteins (BTN1A1, BTN2A2, and BTN3A1) are T cell inhibitory modulators that inhibit cytokine secretion and cell proliferation on anti-CD3 activated T cells. We will also show data identifying ANGPTL proteins as novel LILR receptors and discuss a novel group of proteins termed V-Set And Immunoglobulin Domain-Containing (VSIG).
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OCT 10, 2019 9:00 AM PDT
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Next Generation Targets for Immuno-Oncology
Presented at:
Cancer Research & Oncology 2019
Specialty
Molecular Biology
Assay Development
Cancer Therapeutics
Genomics
Gene Sequencing
Cell Biology
Molecular Diagnostics
Immunology
Oncology
Cancer Research
Animal Research
Medicine
Gene Therapy
Cell Signaling / Transduction
Pcr/rt-Pcr/real-Time Pcr
Geography
North America80%
Asia20%
Registration Source
Website Visitors100%
Job Title
Facility/Department Manager33%
Educator/Faculty33%
Scientist33%
Organization
Academic Institution40%
Hospital20%
Clinical Laboratory20%
Contract Research Organization (Cro)20%
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