NOV 14, 2018 8:00 AM PST

Webinar #1: Copy number analysis in transplant research

Sponsored by: Thermo Fisher Scientific
Speaker
  • Assistant Professor, Dept. of Surgery (Division of Transplantation) and Pediatrics, University of Pennsylvania
    Biography
      Brendan Keating, PhD, received his D.Phil. in molecular genetics from the Department of Clinical Medicine at University of Oxford, UK. He completed a post-doctoral fellowship at the Institute of Translational Medicine and Therapeutics at UPenn, and was a visiting Scientist at the Wellcome Trust Sanger Institute, Cambridge, UK. Dr. Keating has designed and developed genomic tools for cardiovascular related studies resulting in over a hundred genetic discoveries in various metabolic and CVD-related traits.
      Dr. Keating joined the Faculty at Penn in 2012, and has his primary appointment in the Division of Transplantation in the Department of Surgery. His major research interests focus on the analyses of miRNA, mRNA and polymorphisms of donor and recipients genomes, with the aim of delivering individualized treatment of immunosuppression therapies post-transplant, and prediction of genetic signals that may underpin graft rejection and complications of rejection. Dr. Keating is Principal Investigator of genome-wide association studies (GWAS) for solid-organ transplant cohorts within the Children's Hospital of Philadelphia, and of a number of urinary omic studies. He instigated the formation of an international genomics consortium (iGeneTRAIN) for large-scale genomic studies using > 50,000 DNA samples from a number of international transplant studies (www.igenetrain.org). Dr. Keating is also a member of the Pharmacogenomics and Return of Results working groups of the NHGRI electronic medical record and genomics (eMERGE) network which is integrating clinical genetic data into patient's electronic medical records for clinical decision support for individualize dosing of patients. Dr. Keating has led or co-authored over 120 genomic publications and has given over 100 presentations in 25 countries including numerous national and international conferences. Dr. Keating is also PI of a prospective NIH-funded study looking at post-transplant outcomes in 12 North American pediatric renal transplant centers.

    Abstract
    DATE: November 14, 2018
    TIME:  08:00am PST, 11:00am EST
     
    International Genetics & Translational Research in Transplantation Network (iGeneTRAIN) has recently generated genome-wide genotyping data on > 50,000 DNA samples from a number of international transplant studies (www.igenetrain.org). The majority of the samples were genotyped in an Axiom array – heavily based on the UK biobank array with additional content specifically tailored for transplantation studies. We have investigated a spectrum of phenotypes and post-transplant outcomes primarily using single-nucleotide polymorphisms (SNPs) but more recently we have begun large-scale copy number variant (CNV) analyses. We will present some of the existing CNV datasets for cause-of-transplant – as well as our ongoing studies in this area using the Axiom CNV software.
     

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