NOV 12, 2015 10:30 AM PST

Graves' Disease Assessment: Current Trends in Laboratory Testing

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  • Professor, Associated Laboratory Director, Saint-Luc University Hospital, Brussels, Belgium
      Professor Damien Gruson was awarded his degree of Pharmacist and later of Specialist in Laboratory Medicine from the Catholic University of Louvain, Brussels, Belgium. He joined the Department of Laboratory Medicine of the St-Luc University Hospital in 2008. He is now associated laboratory director and leading Endocrine Biology. He is also member of the research unit on Endocrinolgy Diabetes and Nutrition of the Catholic University of Louvain. Pr. D. Gruson has published numerous articles in several international peer-reviewed journals. Pr. D. Gruson is a member of the committee on distance learning of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), of the IFCC task force for young scientists (Chair between 2010 and 2012 and now consultant), a member of the division of Endocrinology of the American Association of Clinical Chemistry. Pr. D. Gruson is also a Fellow of the European Society of Cardiology.


    Hyperthyroidism is an autoimmune disorder caused by the thyroid stimulating antibody (TSI), active against the thyroid-stimulating hormone (TSH) receptor, which stimulates the gland to synthesize and secrete excess thyroid hormone. It affects approximately 1.5% of the worldwide population. Graves’ disease is the most common cause of hyperthyroidism.
    Fast and proper differential diagnosis of Graves’ disease is vital to initiating appropriate treatment as soon as possible. Patient history, physical examination, and diagnostic tools such as imaging and laboratory testing are necessary for proper diagnosis. Choosing the right laboratory tests and interpreting them correctly are critical components of Graves’ disease diagnosis. Currently, a variety of thyroid antibody and hormone assays are available. Understanding the differences between these tests is important to choosing the right assay.

    Learning Objectives

    • Understand how clinicians diagnose and monitor Graves’ disease, and why the TSI assay is beneficial from the clinician’s point of view.
    • Learn about the differences between the TSI assay and a thyroid receptor antibody test called TRab. 
    • Review the laboratory needs for proper Graves’ disease assessment.

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