NOV 12, 2015 10:30 AM PST

Graves' Disease Assessment: Current Trends in Laboratory Testing

Speaker
  • Professor, Head of the Department of Clinical Biochemistry, Cliniques Universitaires Saint Luc
    Biography
      Professor Damien Gruson was awarded his degree of Pharmacist and later of Specialist in Laboratory Medicine from the Catholic University of Louvain, Brussels, Belgium. He is the head of the department of Clinical Biochemistry of the Cliniques Universitaires Saint Luc. He is also member of the research unit on Endocrinology Diabetes and Nutrition of the Catholic University of Louvain. Pr. D. Gruson has published numerous articles in several international peer-reviewed journals. Pr. D. Gruson is member of the division on Emerging Technology of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). Pr. D. Gruson is also Fellow of the European Society of Cardiology.

    Abstract

    Hyperthyroidism is an autoimmune disorder caused by the thyroid stimulating antibody (TSI), active against the thyroid-stimulating hormone (TSH) receptor, which stimulates the gland to synthesize and secrete excess thyroid hormone. It affects approximately 1.5% of the worldwide population. Graves’ disease is the most common cause of hyperthyroidism.
    Fast and proper differential diagnosis of Graves’ disease is vital to initiating appropriate treatment as soon as possible. Patient history, physical examination, and diagnostic tools such as imaging and laboratory testing are necessary for proper diagnosis. Choosing the right laboratory tests and interpreting them correctly are critical components of Graves’ disease diagnosis. Currently, a variety of thyroid antibody and hormone assays are available. Understanding the differences between these tests is important to choosing the right assay.

    Learning Objectives

    • Understand how clinicians diagnose and monitor Graves’ disease, and why the TSI assay is beneficial from the clinician’s point of view.
    • Learn about the differences between the TSI assay and a thyroid receptor antibody test called TRab. 
    • Review the laboratory needs for proper Graves’ disease assessment.

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