Research Fellow, Dana-Farber Cancer Institute, Laboratory of Nathanael Gray
BIOGRAPHY
DEC 04, 2019 9:00 AM PST
Share
New Horizons for Protein Degradation: Immediate, Selective Protein Control Using the dTAG System
Speaker
Abstract
DATE: December 4, 2019
TIME: 9:00am PST, 12:00pm EST
Targeted protein degradation is a novel chemical modality centered on using pharmacological agents to immediately and selectively alter protein abundance. While there is a lack of research tools to perturb the majority of proteins in the proteome, hybrid chemical-genetic degradation systems have emerged as orthogonal means to modulate protein homeostasis. These degradation-based strategies are highly complementary to widely used genetic approaches, while offering improved target selectivity profiles and enabling functional studies with superior kinetic resolution. One novel strategy, the degradation tag (dTAG) system, uses heterobifunctional small molecule degraders to co-opt the cellular degradation machinery to rapidly and selectively dispose of tagged proteins. This webinar will summarize the dTAG technology platform and highlight case studies demonstrating utility for target-specific protein degradation. The dTAG system is a versatile tool for pre-clinical target validation and biological investigation in cellular and mouse models.
Learning Objectives:
- Demonstrate an understanding around the application of targeted protein degradation strategies
- Discover how the dTAG system can be applied to selectively degrade proteins
- Develop insights into how the dTAG system can be used for target validation and mechanistic studies
Webinars will be available for unlimited on-demand viewing after live event.
LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.
You May Also Like
MAY 11, 2021
10:00 AM PDT
C.E. CREDITS
MAY 11, 2021
10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
SEP 14, 2021
7:00 AM PDT
C.E. CREDITS
SEP 14, 2021
7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
JUN 09, 2021
7:00 AM PDT
C.E. CREDITS
JUN 09, 2021
7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
Date: October 12, 2021 Time: 9:00am (PDT), 12:00pm (EDT) SCIEX’s next-generation Biologics Explorer software is an innovative platform for the comprehensive and deep characterization o...
JUL 15, 2021
8:00 AM PDT
C.E. CREDITS
JUL 15, 2021
8:00 AM PDT
Date: July 15, 2021 Time: 8:00am (PDT), 11:00am (EDT) High dimensional full spectrum flow cytometry grants unprecedented access to previously unattainable parameters in cellular biology. Flu...
JUL 15, 2021
9:00 AM PDT
JUL 15, 2021
9:00 AM PDT
Date: July 15, 2021 Time: 9:00am (PDT), 12:00pm (EDT) The Pisces workflow robust, easy-to-use, end-to-end multi-omics solution for highly multiplexed targeted Spatial RNA analysis. VeranomeB...
DEC 04, 2019 9:00 AM PST
Share
New Horizons for Protein Degradation: Immediate, Selective Protein Control Using the dTAG System
Specialty
Molecular Biology
Cell Biology
Cancer Research
Immunology
Biotechnology
Cell Culture
Biochemistry
Genetics
Molecular Diagnostics
Gene Expression
Cancer Therapeutics
Biomarkers
Cell Signaling / Transduction
Dna
Drug Discovery
Geography
North America54%
Europe25%
Asia13%
South America3%
Oceania2%
Africa2%
Registration Source
Website Visitors45%
Email Promotions26%
WAVE Newsletter Promotion4%
Trending Newsletter Promotion2%
Other22%
Job Title
Educator/Faculty17%
Research Scientist14%
Scientist14%
Student14%
Medical Laboratory Technician10%
Executive8%
Clinical Laboratory Scientist5%
Post Doc5%
Facility/Department Manager4%
Chemist2%
Medical Doctor/Specialist2%
Biologist2%
Lab Management2%
Marketing/Sales1%
Consultant1%
Organization
Academic Institution37%
Biotech Company10%
Clinical Laboratory8%
Hospital8%
Pharmaceutical Company7%
Research Institute4%
Medical School3%
Government3%
Life Science Company2%
Contract Research Organization (Cro)2%
Consultant2%
Medical Center2%
Diagnostic Company1%
Government/public1%
Other3%
Loading Comments...
Finish Registering
-
SEP 22, 2021Cell Biology 2021 -
SEP 29, 2021CRISPR 2021
-
OCT 04, 20218th Annual Conference: SBI2 High Content
-
OCT 05, 2021Lab Compliance Connect
-
OCT 06, 2021Cancer Research & Oncology 2021
- See More
