DEC 04, 2019 9:00 AM PST

New Horizons for Protein Degradation: Immediate, Selective Protein Control Using the dTAG System

Speaker

Abstract
DATE:  December 4, 2019
TIME:   9:00am PST, 12:00pm EST
 
Targeted protein degradation is a novel chemical modality centered on using pharmacological agents to immediately and selectively alter protein abundance. While there is a lack of research tools to perturb the majority of proteins in the proteome, hybrid chemical-genetic degradation systems have emerged as orthogonal means to modulate protein homeostasis. These degradation-based strategies are highly complementary to widely used genetic approaches, while offering improved target selectivity profiles and enabling functional studies with superior kinetic resolution. One novel strategy, the degradation tag (dTAG) system, uses heterobifunctional small molecule degraders to co-opt the cellular degradation machinery to rapidly and selectively dispose of tagged proteins. This webinar will summarize the dTAG technology platform and highlight case studies demonstrating utility for target-specific protein degradation. The dTAG system is a versatile tool for pre-clinical target validation and biological investigation in cellular and mouse models.
 
Learning Objectives:
  • Demonstrate an understanding around the application of targeted protein degradation strategies
  • Discover how the dTAG system can be applied to selectively degrade proteins
  • Develop insights into how the dTAG system can be used for target validation and mechanistic studies
 
 
Webinars will be available for unlimited on-demand viewing after live event.
 
LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

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DEC 04, 2019 9:00 AM PST

New Horizons for Protein Degradation: Immediate, Selective Protein Control Using the dTAG System


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