DEC 04, 2019 9:00 AM PST

New Horizons for Protein Degradation: Immediate, Selective Protein Control Using the dTAG System

Speaker
  • Research Fellow, Dana-Farber Cancer Institute, Laboratory of Nathanael Gray
    Biography
      Behnam Nabet, Ph.D. is a Postdoctoral Research Fellow in the laboratory of Dr. Nathanael Gray at the Dana-Farber Cancer Institute. Dr. Nabet received his Ph.D. in Cancer Biology from Northwestern University and B.A. in Biology from the University of Pennsylvania. In his postdoctoral research, Dr. Nabet developed a generalizable technology platform known as the dTAG system to rapidly degrade any target protein of interest. The dTAG system pairs potent small molecule degraders and extensible tagging strategies to achieve selective degradation of divergent proteins. This technology facilitates biological exploration and drug target validation in cells and animal models. Dr. Nabet is currently applying the dTAG platform to investigate pancreatic cancer dependencies and has been sharing his technology with the global scientific community in an open-source manner. Dr. Nabet is supported by an American Cancer Society Postdoctoral Fellowship and is a recipient of the Claudia Adams Barr Program for Innovative Cancer Research award.

    Abstract
    DATE:  December 4, 2019
    TIME:   9:00am PST, 12:00pm EST
     
    Targeted protein degradation is a novel chemical modality centered on using pharmacological agents to immediately and selectively alter protein abundance. While there is a lack of research tools to perturb the majority of proteins in the proteome, hybrid chemical-genetic degradation systems have emerged as orthogonal means to modulate protein homeostasis. These degradation-based strategies are highly complementary to widely used genetic approaches, while offering improved target selectivity profiles and enabling functional studies with superior kinetic resolution. One novel strategy, the degradation tag (dTAG) system, uses heterobifunctional small molecule degraders to co-opt the cellular degradation machinery to rapidly and selectively dispose of tagged proteins. This webinar will summarize the dTAG technology platform and highlight case studies demonstrating utility for target-specific protein degradation. The dTAG system is a versatile tool for pre-clinical target validation and biological investigation in cellular and mouse models.
     
    Learning Objectives:
    • Demonstrate an understanding around the application of targeted protein degradation strategies
    • Discover how the dTAG system can be applied to selectively degrade proteins
    • Develop insights into how the dTAG system can be used for target validation and mechanistic studies
     
     
    Webinars will be available for unlimited on-demand viewing after live event.
     
    LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

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