FEB 22, 2018 10:30 AM PST

Illuminating the Druggable GPCR-ome

Presented at: Drug Discovery 2018
Speaker
  • Michael Hooker Distinguished Professor, Department of Pharmacology and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy
    BIOGRAPHY

Abstract

G-protein coupled receptors (GPCRs) represent the single largest class of druggable targets in the human genome. Of the 390 or so druggable and non-olfactory human GPCRs there exist many which are orphan and/or understudied; we refer to these as "oGPCRs". In this talk I will show how new technologies developed by my lab can illuminate the pharmacology, signaling pathways, chemical biology, distribution and function of GPCrs. I will highlight our new open-source tools which include  open-access repositories of chemical probe molecules, reporter plasmids and engineered animals that enable investigators to interrogate the biological functions of GPCRs. Given the central importance of GPCRs for all areas of biomedical research, illuminating the pharmacology, function, signaling and chemical biology of known GPCRs and oGPCRs will have far-reaching impact for both therapeutics and basic biomedical science.


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FEB 22, 2018 10:30 AM PST

Illuminating the Druggable GPCR-ome

Presented at: Drug Discovery 2018

Specialty

Research And Development

Life Science

University

Immunology

Disease

Epigenetics

Health

Therapy

Animal Research

Hiv

Earth Science

Behavioral Research

Functional Medicine

Virology

Drug Discovery

Geography

North America75%

Asia25%

Registration Source

Website Visitors100%

Job Title

Research Scientist25%

Medical Laboratory Technician25%

Post Doc25%

Lab Management25%

Organization

Pharmaceutical Company25%

Academic Institution25%

Manufacturer - Other25%

Government/public25%


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