Michael Hooker Distinguished Professor, Department of Pharmacology and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy
BIOGRAPHY
FEB 22, 2018 10:30 AM PST
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Illuminating the Druggable GPCR-ome
Presented at:
Drug Discovery 2018
Speaker
Abstract
G-protein coupled receptors (GPCRs) represent the single largest class of druggable targets in the human genome. Of the 390 or so druggable and non-olfactory human GPCRs there exist many which are orphan and/or understudied; we refer to these as "oGPCRs". In this talk I will show how new technologies developed by my lab can illuminate the pharmacology, signaling pathways, chemical biology, distribution and function of GPCrs. I will highlight our new open-source tools which include open-access repositories of chemical probe molecules, reporter plasmids and engineered animals that enable investigators to interrogate the biological functions of GPCRs. Given the central importance of GPCRs for all areas of biomedical research, illuminating the pharmacology, function, signaling and chemical biology of known GPCRs and oGPCRs will have far-reaching impact for both therapeutics and basic biomedical science.
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FEB 22, 2018 10:30 AM PST
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Illuminating the Druggable GPCR-ome
Presented at:
Drug Discovery 2018
Specialty
Research And Development
Life Science
University
Immunology
Disease
Epigenetics
Health
Therapy
Animal Research
Hiv
Earth Science
Behavioral Research
Functional Medicine
Virology
Drug Discovery
Geography
North America75%
Asia25%
Registration Source
Website Visitors100%
Job Title
Research Scientist25%
Medical Laboratory Technician25%
Post Doc25%
Lab Management25%
Organization
Pharmaceutical Company25%
Academic Institution25%
Manufacturer - Other25%
Government/public25%
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