FEB 22, 2018 10:30 AM PST

Illuminating the Druggable GPCR-ome

Presented at: Drug Discovery 2018
Speaker
  • Michael Hooker Distinguished Professor, Department of Pharmacology and Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy
    Biography
      Bryan L. Roth MD, PhD is the Michael Hooker Distinguished Professor of Pharmacology at the University of North Carolina Chapel Hill School of Medicine. Dr. Roth received his MD and PhD (Biochemistry) from St. Louis University in 1983 and subsequently training in pharmacology (NIH), molecular biology and psychiatry (Stanford) . Dr. Roth has published more than 400 papers in the general area of the molecular pharmacology of drug actions, including a large number of papers published in Science, Nature and Cell over the past decade. Dr. Roth has more than 40 patents and has founded 2 companies. Dr. Roth has been elected to the National Academy of Medicine of the National Academy of Sciences and has received many honors including the Goodman and Gilman Award for Receptor Pharmacology (ASPET; 2016), the PhRMA Foundation Excellence in Pharmacology Award, and a NARSAD Distinguished Investigator Award. Dr. Roth also given many endowed lectures including the Goodman, Koppyani, Strongwater, Niznik, Swammerdam, Lowenthal, S.G. Fergusson, Chauncy Leake and Philip S. Portoghese Lectures. Dr. Roth has also been named the 2018 IUHPAR Lecturer in Analytical Pharmacology (IUPHAR), the 2017 Martin S. Rodbell Lecturer and the inaugural 2017 Elliot Saul Vessell Visiting Professor. Dr. Roth has also been named a Thompson Reuters 'Highly Cited Scientist' in Pharmacology and in Biology and Biochemistry.

    Abstract

    G-protein coupled receptors (GPCRs) represent the single largest class of druggable targets in the human genome. Of the 390 or so druggable and non-olfactory human GPCRs there exist many which are orphan and/or understudied; we refer to these as "oGPCRs". In this talk I will show how new technologies developed by my lab can illuminate the pharmacology, signaling pathways, chemical biology, distribution and function of GPCrs. I will highlight our new open-source tools which include  open-access repositories of chemical probe molecules, reporter plasmids and engineered animals that enable investigators to interrogate the biological functions of GPCRs. Given the central importance of GPCRs for all areas of biomedical research, illuminating the pharmacology, function, signaling and chemical biology of known GPCRs and oGPCRs will have far-reaching impact for both therapeutics and basic biomedical science.


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