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Immunity, Aging and COVID-19 : where do we stand?

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Bowman Professor and Head, Department of Immunobiology, Co-Director, University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson
    Biography

      Dr. Nikolich-Zugich is internationally recognized as a leading immunologist and gerontologist. He received his M.D., MSc and Ph.D. in Immunology from Belgrade University and did his postdoc at the Scripps Clinic and Research Foundation with Dr. M.J. Bevan, FRS, NAS, HHMI. He held faculty positions concurrently at the  Memorial Sloan-Kettering Cancer Center, and the Cornell University Graduate School of Medical Sciences, and then at the Oregon Health and Sciences University. From 2008 he is serving as, Bowman Professor and Head, University of Arizona Department of Immunobiology and the Arizona Center on Aging (co-Director).  He is Fellow of the Gerontological Society of America and the American Aging Association. Dr Nikolich investigates, in mouse and human models: (i) basic mechanisms of immunity and how these mechanisms decline and deteriorate with age to erode protective immunity against infection; (ii) how persistent infections such as cytomegalovirus (CMV), modulate immunity and healthspan with aging; (iii) how we can devise methods to correct or ameliorate immune dysfunction by means of new vaccines, immunomodulatory and metabolic intervention and/or immune rejuvenation; and (iv) whether and how different longevity extension treatments can improve function of the immune system while still providing longevity/healthspan benefit.


    Abstract

    SARS-CoV-2 had spread with speed unknown in recent history across the globe, sickening >50M people and killing over 1M.  By far the most of the severe cases and deaths were registered amongst adults older than 65, and often older than 50 years. We will discuss what makes this virus so well suited to disperse and infect so many and be so dangerous to older adults.

    Learning Objectives:

    1. Discuss what is SARS-CoV-2 and how is it different from other coronaviruses

    2. Delineate the disease that this virus produces and what is unexpected in it

    3. Review the immune response to this virus in adult and older populations, including  duration of immunity, and discuss potential immune vulnerability and protection by vaccination


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