In the past several years, there has been an increase in drug testing associated with chronic pain. Immunoassays are the most common method for initial screening which can test for a specific drug, metabolite, or a class of drugs. The drug tests are used routinely in the workplace drug testing and periodic testing for drug compliance. Commercially available immunoassays vary in their features, specificities, and screening thresholds. Therefore, the results should be looked at with understanding of the immunoassay used in the testing and drug metabolism. Immunoassays, which are designed for detection of the abuse of drugs, may be suitable for pain management testing. Immunoassay low cutoff levels may provide laboratories with more sensitive methods for drug monitoring and in identifying abuse and misuse of prescription drugs. This presentation will discuss immunoassay features, commercial drug tests for opioids/other drugs, and their suitability for pain management testing.