MAR 01, 2022 10:00 AM PST

Impaired Dendritic Cell Homing in COVID-19

Sponsored by: Visiopharm®
Speakers

Abstract
Date:  March 01, 2022
Time: 10:00am (PST),  1:00pm (EST), 7:00pm (CEST)
 
The high mortality of COVID-19 is mostly attributed to acute respiratory distress syndrome (ARDS), whose histopathological correlate is diffuse alveolar damage (DAD). Furthermore, severe COVID-19 is often accompanied by a cytokine storm and a disrupted response of the adaptive immune system. Studies aiming to depict this dysregulation have mostly investigated the peripheral cell count as well as the functionality of immune cells. The team at the UK Augsburg in Germany investigated the impact of SARS-CoV-2 on antigen-presenting cells using multiplexed immunofluorescence.
 
Similar to MERS-CoV and SARS-CoV, SARS-CoV-2 appears to be impairing the maturation of dendritic cells (DCs). DC maturation involves a switch in surface antigen expression, which enables the cells’ homing to lymph nodes and the subsequent activation of T-cells. As quantitative descriptions of the local inflammatory infiltrate are still scarce, we compared the cell population of professional antigen-presenting cells (APC) in the lungs of COVID-19 autopsy cases in different stages of DAD. We found an increased count of myeloid dendritic cells (mDCs) in later stages. Interestingly, mDCs also showed no significant upregulation of maturation markers in DAD-specimens with high viral load. Accumulation of immature mDCs, which are unable to home to lymph nodes, ultimately results in an inadequate T-cell response.
 
Learning Objectives
  • Experience how the team used digital analysis of multiplex IF images to learn more about the specific immune landscape in fatal COVID cases
  • Explore the possible effects of SARS-CoV-2 and related coronaviridae on antigen presenting cells
  • Understand the role of the UKA in COVID-19 autopsies
 
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