MAR 18, 2021 9:00 AM PDT

Improved Biopharmaceutical Characterization Workflows for Next Generation mAb Based Therapeutics

Sponsored by: SCIEX
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Sr. Mgr. Applications, SCIEX, USA; Member of the Hungarian Academy of Sciences
    Biography
      András Guttman leads the biopharma related separation-application efforts at SCIEX, also heading the Horváth Csaba Memorial Laboratory of Bioseparation Sciences in University of Debrecen, Hungary. His work is focused on capillary electrophoresis and CESI-MS based glycomics and glycoproteomics analysis of biomedical and biopharmaceutical interests, with special attention to biosimilarity and new modalities in the industry. Dr Guttman has over 325 scientific publications, wrote 35 book chapters, edited 4 textbooks and holds 25 patents. He is an external member of the Hungarian Academy of Sciences, on the board of several international scientific organizations, serves as editorial board member for a dozen scientific journals and editor in chief for Current Molecular Medicine. He has been recognized by numerous awards including the Analytical Chemistry Award of the Hungarian Chemical Society in 2000, named as Fulbright Scholar in 2012, received the CASSS CE Pharm Award in 2013, the Arany Janos medal of the Hungarian Academy of Sciences, the Pro Scientia award of the University of Pannonia and the Dennis Gabor Award of the Novofer Foundation in 2014. Dr Guttman is also the recipient of the 2017 Dal Nogare Award of the Delaware Valley Chromatography Forum and the Grand prize of the Swedish Chamber of Commerce.

    Abstract
    Date:  March 18, 2021
    Time: 9:00am (PST),  12:00am (EST)
     
    As novel therapeutic modalities progress through development, improved analytical techniques are required to overcome characterization challenges. This presentation will overview various high resolution separation techniques and their application toward analyzing the next generation of complex biotherapeutic modalities. The audience will learn how electric field mediated separation methods can be utilized in identifying important post translational modifications influencing safety and efficacy characteristics of a drug. Additionally, common separation challenges relating to deamidated species, hydrophobic and hydrophilic peptides, and low abundant glycoforms are addressed with improved capillary electrophoresis workflows.
     
    Learning Objectives
    • Compare analytical techniques and understand their application toward biotherapeutic characterization
    • Describe rapid workflows to assess the charge heterogeneity of therapeutic proteins
    • Illustrate advantages of capillary electrophoresis based methods for quality attribute monitoring
     
     
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