Improved Biopharmaceutical Characterization Workflows for Next Generation mAb Based Therapeutics

As novel therapeutic modalities progress through development, improved analytical techniques are required to overcome characterization challenges. This presentation will overview various high resolution separation techniques and their application toward analyzing the next generation of complex biotherapeutic modalities. The audience will learn how electric field mediated separation methods can be utilized in identifying important post translational modifications influencing safety and efficacy characteristics of a drug. Additionally, common separation challenges relating to deamidated species, hydrophobic and hydrophilic peptides, and low abundant glycoforms are addressed with improved capillary electrophoresis workflows.

 

Learning Objectives