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Improvements in building in vitro pluripotent stem cell-derived disease models

Speaker

Abstract

The discovery of the CRISPR/Cas9 system has transformed research and now allows straightforward alterations in the genome and can be exploited to introduce changes to mimic diseases. This presentation will highlight the use of CRISPR/Cas9 in the generation of disease models in that are relevant for Parkinson’s disease. A review of our ongoing work on the development of pluripotent stem cell (PSC)-based disease models in the neuronal contexts covers which tools can be used to perform CRISPR/Cas9 based genome editing in PSC, how clonal isolation of edited PSC can be dramatically improved, how edited cells are characterized and how differentiation into the relevant cell type is used to reveal cellular phenotypes caused by the genetic changes.


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Improvements in building in vitro pluripotent stem cell-derived disease models


Specialty

Gene Sequencing

Cancer Diagnostics

Dna Sequencing

Oncology

Biomarkers

Protein

Immunology

Cell Culture

Cancer Research

Dna

Clinical Diagnostics

Immuno-Oncology

Gene Expression

Biotechnology

Drug Discovery

Geography

Asia50%

North America25%

Europe25%

Registration Source

Website Visitors100%

Job Title

Student33%

Educator/Faculty33%

Scientist33%

Organization

Academic Institution50%

Life Science Company25%

Wholesale/retail Trade25%


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