NOV 06, 2019 12:00 PM PST

A dose of the flu: influenza's variable virus particles

Presented at: Influenza 2019
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Research Fellow (Centre for Virus Research), University of Glasgow
    Biography
      Ed Hutchinson began working on the molecular biology of influenza viruses as a PhD student with Prof Paul Digard (then at the University of Cambridge), and then continued with research in this area at the University of Oxford, as a postdoc with Prof Ervin Fodor and as a Junior Research Fellow at Worcester College. In 2016, he used an MRC Career Development Award to set up a research group at the MRC-University of Glasgow Centre for Virus Research.

    Abstract

    Influenza viruses are transmitted by membrane-bound virus particles, or virions. Unlike some viruses, which produce near-identical virions from a well-defined set of viral components, influenza virions are assembled from shifting mixtures of viral and host components and vary markedly in their size, shape and composition. In this talk we will show how a variety of advanced methods can be combined to explore the complex structure of influenza virions. We will examine sources of variation in influenza virions and discuss the challenges this variation creates for understanding how influenza viruses infect new cells.

    Learning Objectives:
    1. Gain a detailed understanding of the structure and composition of the virus particles that transmit influenza infections.
    2. Understand that the idea of a single type of influenza virus particle is a simplification, and that in fact influenza infections involve interactions between a highly variable mixture of different particles.


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