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Insights into SARS-CoV-2 Biology

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Professor, Departments of Microbiology and Medicine, Tisch Cancer Center Icahn School of Medicine at Mount Sinai
    Biography
      Dr. García-Sastre is Professor in the Departments of Microbiology and Medicine and in the Tisch Cancer Center at Icahn School of Medicine Mount Sinai (ISMMS) in New York,. He is also Director of the Global Health and Emerging Pathogens Institute at ISMMS, and Principal Investigator for the Center for Research on Influenza Pathogenesis (CRIP), one of five NIAID Centers of Excellence for Influenza Research and Surveillance (CEIRS). For the past 30 years, his research interest has been focused on the molecular biology, virus-host interactions, innate immunity and pathogenesis of influenza viruses and several other RNA viruses, as well as on the development of new vaccines and antivirals. He has more than 500 peer-reviewed publications in these areas of research. He has been President of the International Society for Vaccines in 2014-2015. He is Editor for the scientific journals PLoS Pathogens, Journal of Virology and Virus Research. In 2017, he has been elected a fellow of the Royal Academy of Pharmacy in Spain. In 2019, he was recognized with a Honorary Doctor Degree from the University of Burgos, Spain. Also in 2019, he was elected a member of the National Academy of Sciences.

    Abstract

    As part of a large collaborative effort, we have used systems biology approaches to identify host factors that participate in SARS-CoV-2 replication.  Protein-protein interactions maps between viral and host proteins and  global landscapes on protein phosphorylation changes taking place in SARS-CoV-2 infected cells were used as guides for the identification of host processes that could be targeted for antiviral therapeutic intervention. Drugs known to interact with these host processes and with known clinical profiles were tested for their ability to inhibit SARS-CV-2 replication in tissue culture.   As a result, we found several promising therapeutic candidates to be evaluated in vivo for the treatment of COVID-19.

    Learning Objectives:

    1. Understand the concept of drug re-purposing

    2. Gain insights on the use of system biology approaches for the discovery of antivirals

    3. Gain insights on the host-virus protein interactions contributing to SARS-CoV-2 replication


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