NOV 14, 2019 10:30 AM PST

Interferences with thyroid function tests and patient safety

Speakers
  • Professor, Head of the Department of Clinical Biochemistry, Cliniques Universitaires Saint Luc
    Biography
      Professor Damien Gruson was awarded his degree of Pharmacist and later of Specialist in Laboratory Medicine from the Catholic University of Louvain, Brussels, Belgium. He is the head of the department of Clinical Biochemistry of the Cliniques Universitaires Saint Luc. He is also member of the research unit on Endocrinology Diabetes and Nutrition of the Catholic University of Louvain. Pr. D. Gruson has published numerous articles in several international peer-reviewed journals. Pr. D. Gruson is member of the division on Emerging Technology of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). Pr. D. Gruson is also Fellow of the European Society of Cardiology.

    Abstract:

    Thyroid function tests play a central role to assess thyroid function and are valuable companions for clinicians. The evolution of the tests is permanent and clinical laboratories are key players in defining decision limits and validating new methods. In addition, several standardization efforts are also underway and will have an impact on test performance.

    However, thyroid function tests can be sensitive to different types of interference and therefore have an impact on the clinical decision. Such interference may be suspected in the event of clinical and / or biological discrepancies. Their identification is based on additional laboratory tests including a comparison of assay methods, dilution procedures, blocking reagent studies, and polyethylene glycol precipitation. Interdisciplinary exchanges with clinical teams are essential to identify these interferences and continue to improve the performance of our assays.


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