How intracellular metabolic change governs immunity and inflammation

C.E. Credits: P.A.C.E. CE Florida CE
Speaker

Abstract

In this webinar, Dr. Luke O'Neill will discuss an overview of immunology and immunometabolism in infectious disease. The past 10 years or so has seen a major resurgence of interest in immunometabolism. Metabolic changes in immune cell activation has become a focus and the role of glycolysis and Krebs Cycle in the altered phenotype of macrophages and T cells has been explored in detailed. Metabolite such as succinate and itaconate have been probed and the potential to target metabolic change for is gaining momentum.

 

Learning Objectives:

1. PKM2 as key regulator of inflammatory macrophage activation and Th17 cell function

2. Itaconate as anti-inflammatory metabolite that targets multiple inflammatory processes, notably NLRP3

3. Broader context of how viruses subvert immunometabolism and how this might be useful in current studies


Show Resources
You May Also Like
FEB 19, 2020 11:00 AM PST
C.E. CREDITS
FEB 19, 2020 11:00 AM PST
DATE: February 19, 2020TIME: 11:00am PST, 2:00pm EST...
JUN 17, 2020 1:30 PM PDT
C.E. CREDITS
JUN 17, 2020 1:30 PM PDT
Understanding the complex interplay between a pathogen and the host response is important to developing effective vaccines and therapeutics. The nCounter® Analysis System and GeoMx®...
MAR 11, 2020 6:00 AM PDT
C.E. CREDITS
MAR 11, 2020 6:00 AM PDT
The locomotion of humans and other animals requires a seamless flow of information from sensory modalities all the way to the motor periphery. As such, locomotion is an excellent system for...
APR 30, 2020 8:00 AM PDT
C.E. CREDITS
APR 30, 2020 8:00 AM PDT
DATE:April 30, 2020 TIME: 8AM PT, 11AM ET, 4PM BST, 5PM CEST Cytokinesis is the physical separation of two cells that occurs after the completion of mitosis. The mechanism underlying it is v...
APR 07, 2020 8:00 AM PDT
C.E. CREDITS
APR 07, 2020 8:00 AM PDT
DATE: April 7, 2020 TIME: 8:00am PT, 11:00am ET This webinar sets out to establish why quality control is key to robust, reliable, reproducible science. We will look at best practice criteri...
AUG 26, 2020 8:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
C.E. CREDITS
AUG 26, 2020 8:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
DATE: August 26, 2020 TIME: 8:00 am PDT The host immune "recognition" of cancer forms the basis of modern tumor immmunotherapy, a highly targeted treatment option with the demonstr...
Loading Comments...
Show Resources