How intracellular metabolic change governs immunity and inflammation

C.E. Credits: P.A.C.E. CE Florida CE
Speaker

Abstract

In this webinar, Dr. Luke O'Neill will discuss an overview of immunology and immunometabolism in infectious disease. The past 10 years or so has seen a major resurgence of interest in immunometabolism. Metabolic changes in immune cell activation has become a focus and the role of glycolysis and Krebs Cycle in the altered phenotype of macrophages and T cells has been explored in detailed. Metabolite such as succinate and itaconate have been probed and the potential to target metabolic change for is gaining momentum.

 

Learning Objectives:

1. PKM2 as key regulator of inflammatory macrophage activation and Th17 cell function

2. Itaconate as anti-inflammatory metabolite that targets multiple inflammatory processes, notably NLRP3

3. Broader context of how viruses subvert immunometabolism and how this might be useful in current studies


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