APR 30, 2018 08:00 AM PDT

Ion Mobility/Mass Spectrometry for Metabolomics and Clinical Research Analysis

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  • Colonel Allen R. and Margaret G. Crow Professor and Head, Analytical Chemistry, University of Florida; Director, NIH Southeast Center for Integrated Metabolomics
      Dr. Yost is the Colonel Allen R. and Margaret G. Crow Professor and Head of Analytical Chemistry at the University of Florida. He is recognized internationally as a leader in the field of analytical chemistry, particularly tandem mass spectrometry (MS/MS). He may be best known for inventing (as a graduate student with Chris Enke at Michigan State University) the triple quadrupole mass spectrometer, which 40 years later represents over $1B in sales each year. Dr. Yost's professional activities have focused on research and teaching in analytical mass spectrometry, particularly tandem mass spectrometry (MS/MS). His group's research has reflected a unique balance between instrumentation development, fundamental studies, and applications in analytical chemistry. His group has led in the application of novel mass spectrometric methods and techniques to areas such as metabolomics, clinical, biomedical, pharmaceutical, environmental, and forensic chemistry. Dr. Yost has supervised the research of well over 100 graduate students during the past 37 years, graduating over 85 PhDs from his group. He has served as PI or Co‐PI on grants and contracts totaling over $50M of funding. Research in the group has led to almost 200 publications and 16 patents. He still loves teaching undergraduates and graduates in the classroom each semester. Dr. Yost recently completed terms on the Florida Board of Governors (Regents) and the University of Florida Board of Trustees. He is director of the NIH‐funded Southeast Center for Integrated Metabolomics. He is also a Professor of Pathology at the University of Florida. His research has been recognized with the highest award in his discipline, the 1993 ASMS Award for Distinguished Contribution in Mass Spectrometry, as well as the 2018 MSACL Award for Distinguished Contribution in Clinical Mass Spectrometry. He currently serves as the VP for Programs of ASMS, and will become President in July.


    DATE: April 30, 2018
    TIME: 8:00AM PT,  11:00AM ET

    Ion mobility/mass spectrometry has tremendous potential for metabolomics, lipidomics, and clinical  analysis. Ion mobility can resolve compounds unresolved by LC/MS/MS, provide additional structural  information not available from mass spectrometry, and reduce or eliminate the need for  chromatographic separation. These features offer significant improvements for quantitative targeted  metabolomics and clinical research analysis, as well as for untargeted (global) metabolomics studies.

    This presentation will explore innovations in ion mobility/mass spectrometry for metabolomics,  lipidomics, and clinical research analysis. Techniques to be covered include both classic drift tube ion mobility  (IMS) and high‐field asymmetric‐waveform ion mobility (FAIMS), in conjunction with HRMS, MS/MS, and  LC/MS. Characterization and optimization of instrumental parameters critical for analytical performance will be explored, including ionization techniques, cationization and complexation of analytes for  improved mobility separation, and integration with chromatographic separation and MS/MS.  Applications will include a range of metabolomics, lipidomics, and targeted clinical research analyses. Specific examples will include rapid clinical research assays (vitamin D and its epimers), separation of isomeric  performance‐enhancing steroids, breath analysis research for potential early disease screening, and improvements in mass spec imaging. Recent advances in these areas will be highlighted, along with a perspective on the  metabolomics and clinical future of these approaches.

    Learning Objectives:

    • To understand how ion mobility is combined with mass spectrometry
    • To understand how in mobility/mass spectrometry can be used for clinical research analysis and metabolomics



    For Research Use Only. Not for use in diagnostic procedures.

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