MAY 29, 2014 07:30 AM PDT

Is Cervical Cancer a preventable Disease in women? The role of HPV as a screening test.

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  • Professor of Pathology, Contract Staff - Clinical & Molecular Virology. Center of Pediatric Research, Cleveland Clinic, Cleveland, Ohio
      Belinda Yen-Lieberman, Ph.D., is a Professor of Pathology at the Cleveland Clinic Lerner College of Medicine. She is board certified in clinical virology (Am Society for Clinical Pathology). Dr. Yen-Lieberman received her Bachelor of Science degree in microbiology from Southern Illinois University and her Master of Science and Doctorate degrees in Immunology and biochemistry at the University of Arkansas, Fayetteville, Arkansas. She completed fellowships in clinical and cellular immunology at Case Western Reserve University and the Cleveland Clinic Foundation.

      Dr. Yen-Lieberman has authored over one hundred thirty articles for numerous medical journals on a wide range of topics involving viruses and infectious disease, including studies involving HIV, Hepatitis B , Hepatitis C and Influenza A vaccine, tests for herpes simplex types 1 and 2, and tuberculosis. For the past 24 years, she was the medical director of clinical and Molecular Virology and Serology in Department of Laboratory Medicine. Since July 2015, Dr. Yen-Lieberman is a contract staff in Lab Medicine and Center for Pediatric Research (as clinical virologist). She is responsible for teaching Pathology residents, medical students in CCLCM and students from Cleveland Clinic Medical Technology School. She also participates in various clinical trial studies and research projects including the role of respiratory viruses in childhood asthma.


    Human papillomavirus (HPV) is the primary cause of cervical cancer and more than 100 types of HPV have been identified. Detection of HPV from cervical samples is associated with a 250 times increased risk of high grade cervical neoplasm. Approximately 30 HPV types were reported to infect primarily the squamous epithelium of the lower anogenital tracts of men and women. Worldwide, Cervical Cancer is much more common particularly in countries without screening programs, with an estimated 530,000 new cases of the disease and 275,000 resultant deaths each year (Farlay J, et al. 2008 and Arbyn M, et al 2011). When cervical cancer screening programs have been introduced into communities, marked reductions in cervical cancer incidence have followed (Gustafsson L, et al 1997).

    Human Papillomavirus is one of the most common sexually transmitted infections (STI) in the United States in women, with approximately 6.2 million cases diagnosed annually. The American Cancer Society estimates that there will be 12,170 new cases of cervical cancer in the United States in 2012, with 4,220 deaths from the disease ( Siegel R et al. 2012).

    Learning Objectives:

    At the completion of the presentation, the learners should know:
    1. What is Human Papilloma virus (HPV)
    2. HPV is the primary causal factor of cervical cancer and cervical disease in Women
    3. HPV is one of the most common sexually transmitted infections the the USA
    4. HPV vaccines are available for young men and young women
    5. Why is HPV testing important in women?

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