NOV 17, 2020 8:00 AM PST

Key Features of Immune Cells During SARS-CoV2 Infection

Speaker
  • Assistant Professor, General Pathology and Immunology, School of Medicine, University of Modena and Reggio Emilia, Modena - Italy and ISAC Marylou Ingram Scholar
    BIOGRAPHY

Abstract

Date:  November 17, 2020

Time: 8:00am PST and 5:00pm PST.

* When registering for this event, you will access to both live broadcasts.

 

COVID-19 is a complex pathological condition caused by infection with SARS-CoV. Different features have been observed in samples with a severe SARS-CoV-2 infection, one of these is the progressive increase of immune-mediated inflammation. Indeed, several reports have described abnormally increased levels of cytokines in plasma from samples infected by SARS-CoV-2, that has been defined “cytokine storm,” similarly to what described in bacterial sepsis or after CAR-T cell therapy. We have deeply investigated by flow cytometry the immune system and cells producing cytokines in samples affected by SARVS-CoV-2 in 21 samples and 13 controls. Sampes show an increased percentage of activated, exhausted T lymphocytes. B cell compartment showed even greater modifications, with decreased naïve and memory cells. Monocytes showed relevant signs of functional exhaustion, while neutrophils expressed more markers linked to degranulation. We found that in vitro stimulation caused a relevant production of TNF-α, IFN-γ and IL–2, as well as a significant skewing towards the Th17 phenotype.

 

Learning Objectives

  • Present the Cytokine Storm consequences in SARS-CoV-2 affected individuals on the key features and functionality of the immune cells during SARS-CoV-2 infection
  • Outline the alterations of the T lymphocytes compartment and their impact on the progression of disease
  • Discover additional novel strategies to treat patients infected by SARS-CoV-2

 

 

Webinars will be available for unlimited on-demand viewing after live event.

 

LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety. For UK participants, please contact the IBMS to apply for credits for this course. Click here for details.


Show Resources
You May Also Like
NOV 30, 2021 10:00 AM PST
C.E. CREDITS
NOV 30, 2021 10:00 AM PST
Date: November 30, 2021 Time: 10:00am (PDT), 1:00pm (EDT) The prevalence of thyroid disease worldwide has served as a catalyst for healthcare providers to study various tools and methods to...
DEC 01, 2021 7:00 AM PST
C.E. CREDITS
DEC 01, 2021 7:00 AM PST
Date: December 01, 2021 Time: 7:00am (PST), 10:00am (EST) In the era of immuno-oncology, there is a growing need for the identification of new biomarkers predictive for sensitivity to anti-P...
MAY 17, 2022 9:00 AM PDT
MAY 17, 2022 9:00 AM PDT
Date: May 17, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 8:00pm (CEST) Gene therapeutics have great potential to treat many severe diseases in an unprecedented, targeted manner. The biopharmace...
APR 28, 2022 8:00 AM PDT
APR 28, 2022 8:00 AM PDT
Date: April 28, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Human pluripotent stem cells (PSCs) and their derivatives hold great potentials in...
JAN 13, 2022 9:00 AM PST
C.E. CREDITS
JAN 13, 2022 9:00 AM PST
Date: January 13, 2022 Time: 09:00am (PST), 12:00pm (EST) Recently, the Infectious Disease Society of America released guidance on how to approach treatment of infections caused by multidrug...
MAR 16, 2022 8:00 AM PDT
C.E. CREDITS
MAR 16, 2022 8:00 AM PDT
Date: March 16, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CET) Handling of potent and/or hazardous substances is commonplace in sev.....
Loading Comments...
Show Resources