MAY 11, 2016 9:00 AM PDT

Keynote: Empirical Data on the Path to Genomic Medicine

Speaker
  • Director, G2P Research Program (genomes2people.org), Division of Genetics, Brigham and Women's Hospital, Broad Institute, Harvard Medical School
    Biography
      Robert C. Green, MD, MPH is a medical geneticist and physician-scientist who directs the G2P Research Program (genomes2people.org) in translational genomics and health outcomes in the Division of Genetics at Brigham and Women's Hospital, the Broad Institute and Harvard Medical School. Dr. Green is internationally recognized for designing and conducting empirical research that is accelerating the responsible implementation of genomic medicine. He led the first experimental trials disclosing common complex disease risk (the REVEAL Study) and one of the first prospective studies of direct-to-consumer genetic testing services (the PGen Study). He currently leads and co-leads the first randomized trials to explore the implementation of medical sequencing in adults (the MedSeq Project) and newborns (the BabySeq Project), respectively.

    Abstract

    In this time of incredible promise for genomic medicine, the Genomes2People (G2P) Research Program in Translational Genomics and Health Outcomes, directed by Robert C. Green, MD, MPH, is creating a deep body of knowledge on the medical, behavioral and economic implications of genomic analysis. Through its research, G2P is helping to set the stage for the use of genomic information in promoting health, preventing or mitigating disease, and reducing healthcare costs.

    Dr. Green will summarize his research program that for 15 years has focused on the collection of clinical outcomes data using multiple modalities, including randomized controlled trials (RCT), surveys, demonstration projects and other methodologies. Dr. Green will summarize key research studies and results that comprise the G2P Research Program. He will discuss the history of returning predictive genetic risk information, beginning with the REVEAL Study of returning APOE-related risks, and will present an overview of the projects that have rigorously tracked medical, behavioral and economic outcomes associated with evolving applications of genetic and genomic testing. These include: the PGen Study of consumer genetic testing; the MedSeq Project, a RCT exploring the integration of genome sequencing (GS) into the clinical care of healthy adults and adults with cardiomyopathy; the BabySeq Project, a RCT investigating the use of GS in screening healthy and sick infants for childhood risks and newborn illness; and the PeopleSeq Consortium, a longitudinal survey of ostensibly healthy cohorts that have received GS results. He will end by previewing upcoming initiatives and collaborations that are poised to inform the future implementation of genomic medicine, particularly in understudied populations and contexts with unique ELSI challenges.


    Show Resources
    You May Also Like
    JAN 23, 2020 9:00 AM PST
    C.E. CREDITS
    JAN 23, 2020 9:00 AM PST
    DATE: January 23, 2020 TIME: 9:00am PST, 12:00pm EST...
    APR 07, 2020 8:00 AM PDT
    C.E. CREDITS
    APR 07, 2020 8:00 AM PDT
    DATE: April 7, 2020 TIME: 8:00am PT, 11:00am ET This webinar sets out to establish why quality control is key to robust, reliable, reproducible science. We will look at best practice criteri...
    FEB 19, 2020 11:00 AM PST
    C.E. CREDITS
    FEB 19, 2020 11:00 AM PST
    DATE: February 19, 2020TIME: 11:00am PST, 2:00pm EST...
    MAY 08, 2020 10:00 AM PDT
    C.E. CREDITS
    MAY 08, 2020 10:00 AM PDT
    DATE: May 8, 2020 TIME: 10:00am PT, 11:00am MT, 1:00pm ET The application of next generation sequencing to interrogate immune repertoires and methods in which these highly complex dataset...
    FEB 26, 2020 9:00 AM PST
    C.E. CREDITS
    FEB 26, 2020 9:00 AM PST
    DATE: February 26, 2020 TIME: 9:00am PST 3D cell culture and analysis and the study of organoids and spheroids are becoming more prevalent as a research method in publications as traditional...
    DEC 05, 2019 5:00 AM PST
    C.E. CREDITS
    DEC 05, 2019 5:00 AM PST
    DATE: December 5, 2019TIME: 5:00am PST, 8:00am EST The diagnosis of an active infection by the hepatitis B virus (HBV) relies on testing for the HBV surface antigen (HBsAg). Ov...
    Loading Comments...
    Show Resources
    Attendees
    • See more