MAY 28, 2020 9:00 AM PDT

Detection of Chemical Agents in Bone by LC-MS

Speaker

Abstract

A recently proposed model for the incorporation of xenobiotics of clinical research and forensic interest into the human skeleton suggests nerve agent metabolites may incorporate into bone at relatively elevated levels based on their unique chemical properties. To assess this possibility, methods for the extraction, isolation, and semi-quantitative detection of nerve agent metabolites (corresponding to VX, Russian VX, sarin, cyclosarin, and soman) from bone were developed using liquid chromatography mass spectrometry with both quadrupole time-of-flight (QToF) and triple quadrupole (QqQ) instruments.

Learning Objectives:

1. Understand LC-HRMS method development

2. Identify the clinical research of bone

 

For Research Use Only. Not for use in diagnostic procedures.


Show Resources
You May Also Like
MAY 17, 2022 9:00 AM PDT
MAY 17, 2022 9:00 AM PDT
Date: May 17, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 8:00pm (CEST) Gene therapeutics have great potential to treat many severe diseases in an unprecedented, targeted manner. The biopharmace...
JUN 28, 2022 7:00 AM PDT
JUN 28, 2022 7:00 AM PDT
Date: June 28, 2022 Time: 3:00pm (BST), 4:00pm (CET), 9:00am (CST), 7am (PST) Light-sheet microscopy is an extremely versatile imaging technique with a vast range of implementations that are...
JUN 21, 2022 6:00 AM PDT
JUN 21, 2022 6:00 AM PDT
Date: June 21, 2022 Time: 6:00am (PDT), 9:00am (EDT), 3:00pm (CEST) The global understanding and practice of medicine is currently undergoing a revolutionary change. This shift to precision...
AUG 24, 2022 7:00 AM PDT
AUG 24, 2022 7:00 AM PDT
Date: August 24, 2022 Time: 7:00am (PDT), 10:00pm (EDT), 4:00pm (CEST) Light field microscopy was first introduced in 2006, and allows users to capture the 4D light field within the microsco...
SEP 13, 2022 8:00 AM PDT
SEP 13, 2022 8:00 AM PDT
Date: September 13, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Preparedness against pandemic diseases demands rapid-response vaccine technology and ready-to-use analytical methods...
AUG 10, 2022 10:00 AM PDT
AUG 10, 2022 10:00 AM PDT
Date: August 10, 2022 Time: 10:00am PDT, 1:00pm EDT The global pandemic has increased focus and scrutiny on molecular diagnostic assay development, resulting in a need for assays that provid...
Loading Comments...
Show Resources