MAY 12, 2016 12:00 PM PDT

Learning Biology from Networks and their Structure

Speaker
  • Instructor, Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School
    BIOGRAPHY

Abstract

Network models are an invaluable tool for integrating multiple data types and for modeling interactions between biological elements. One common question that arises, however, is what to do with such a network beyond making a pretty picture. In this talk, I will describe two applications in which we have used network structure to explain features of biological systems. In the first, we construct bipartite eQTL networks from genotype and gene expression data collected by the GTEx consortium. In the second, we explore the response of gene regulatory networks in Mycobacterium tuberculosis to a targeted drug treatment. In both cases, we find that the network structural properties reflect constraints operating on each biological system, and that each network has its own unique, informative feature set. For example, in the eQTL networks, we find the global hubs are not very informative but degree is very useful in interpreting the tuberculosis regulatory network. I will also discuss statistical testing and validation of these networks using functional annotation and wet lab experiments.


Show Resources
You May Also Like
FEB 15, 2023 7:00 AM PST
FEB 15, 2023 7:00 AM PST
Date: February 15, 2023 Time: 7:00am (PST), 10:00pm (EST), 4:00pm (CET) While not all microscopy samples can fluoresce, all can scatter light, and this scattered light can be imaged. This ha...
AUG 16, 2022 11:00 AM PDT
AUG 16, 2022 11:00 AM PDT
Date: August 16, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CEST) Understanding genomic variation in the context of cancer is paramount to identifying disease drivers and informing pers...
SEP 22, 2022 9:00 AM PDT
SEP 22, 2022 9:00 AM PDT
Date: September 22, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Optimizing platforms for surgical specimen collection and deep human phenotyping was used to enhance protein biomarke...
AUG 24, 2022 7:00 AM PDT
AUG 24, 2022 7:00 AM PDT
Date: August 24, 2022 Time: 7:00am (PDT), 10:00pm (EDT), 4:00pm (CEST) Light field microscopy was first introduced in 2006, and allows users to capture the 4D light field within the microsco...
OCT 13, 2022 9:00 AM +08
OCT 13, 2022 9:00 AM +08
First Broadcast: Date: October 12, 2022 Time: 8:00am PDT, 11:00am EDT Second Broadcast: Date: October 12, 2022 Time: 9:00am SGT The new Embedded CryoSPARC Live, now fully integrated with t...
AUG 10, 2022 10:00 AM PDT
AUG 10, 2022 10:00 AM PDT
Date: August 10, 2022 Time: 10:00am PDT, 1:00pm EDT The global pandemic has increased focus and scrutiny on molecular diagnostic assay development, resulting in a need for assays that provid...
MAY 12, 2016 12:00 PM PDT

Learning Biology from Networks and their Structure



Show Resources
Loading Comments...
Show Resources