APR 25, 2019 6:00 AM PDT

Long-Read Sequencing and Infectious Disease: New Insights Into Longstanding Challenges

Sponsored by: PacBio
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Director, Market Strategy for Microbial and Cancer Genomics, Pacific Biosciences
    Biography
      Meredith Ashby is the Director of Market Strategy for Microbial Genomics, Cancer and Immunology at Pacific Biosciences. She completed her Ph.D. at Caltech mapping the gene regulatory networks that direct sea urchin development just as the sea urchin genome was being sequenced. Inspired by the impact of genome sequencing on her research, she joined PacBio after a postdoc at UCSF. She has been with the company since 2009 and has worked in R&D on both sequencing optimization and bioinformatics application development. She is now focused on facilitating the use of PacBio long read sequencing to solve the unmet needs of scientists seeking to understand the incredibly diverse range of microbes that live in, on and around us and the systems we depend on.

    Abstract

    To reduce the global burden diseases causes by infectious disease, including parasites and bacteria, scientists need better information about mechanisms of virulence, immune evasion, and drug resistance, as well as new insights into parasite and pathogen vector biology and life cycles.  One of the longstanding challenges in infectious disease has been the lack of high-quality reference genomes.  Parasite genomes in particular have been highly fragmented, as the telomeric regions of their chromosomes are dense with highly homologous genes that cannot be resolved with short read sequencing.  Recent developments in genome sequencing, however, are helping researchers overcome this barrier.  Recently, highly contiguous genome assemblies of Plasmodium falciparum, Aedes aegypti, and multiple trypanosomes have become available.  The number of reference genomes for bacteria that cause infectious disease is similarly expanding rapidly. Join Dr. Ashby as she discusses now these new resources are already yielding new biological insights into critical questions in infectious disease research, including how parasites evade the immune system add how pathogens are adapting to evolutionary pressures.

    Learning Objectives:

    1. Understand how the structure of parasite genomes facilitates immune evasion and rapid adaptation while at the same time creating challenges for high-quality genome assembly.
    2. Discuss how long-read sequencing and high-quality references facilitate the identification of genomic changes linked to selective pressure, either directly or in conjunction with short read data.


    Show Resources
    You May Also Like
    APR 07, 2020 8:00 AM PDT
    C.E. CREDITS
    APR 07, 2020 8:00 AM PDT
    DATE: April 7, 2020 TIME: 8:00am PT, 11:00am ET This webinar sets out to establish why quality control is key to robust, reliable, reproducible science. We will look at best practice criteri...
    FEB 26, 2020 9:00 AM PST
    C.E. CREDITS
    FEB 26, 2020 9:00 AM PST
    DATE: February 26, 2020 TIME: 9:00am PST 3D cell culture and analysis and the study of organoids and spheroids are becoming more prevalent as a research method in publications as traditional...
    MAY 08, 2020 10:00 AM PDT
    C.E. CREDITS
    MAY 08, 2020 10:00 AM PDT
    DATE: May 8, 2020 TIME: 10:00am PT, 11:00am MT, 1:00pm ET The application of next generation sequencing to interrogate immune repertoires and methods in which these highly complex dataset...
    JUN 17, 2020 1:30 PM PDT
    C.E. CREDITS
    JUN 17, 2020 1:30 PM PDT
    Understanding the complex interplay between a pathogen and the host response is important to developing effective vaccines and therapeutics. The nCounter® Analysis System and GeoMx®...
    OCT 08, 2020 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    OCT 08, 2020 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: October 8, 2020 TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop thinking about ho...
    JUN 09, 2020 10:00 AM PDT
    C.E. CREDITS
    JUN 09, 2020 10:00 AM PDT
    DATE: June 9, 2020 TIME: 10:00am PT, 1:00pm ET The presentation will first discuss sepsis as a disease and then explain the importance of performing diagnostic tests in the clinical labora...
    Loading Comments...
    Show Resources
    Attendees
    • See more