Her scientific research focuses on standardization, harmonization and trueness verification of medical test results, for the sake of better of patient care. Her scientific work is done in close collaboration with the Dutch External Quality Assessment Scheme organizer (SKML) and with international colleagues which collaborate in joint working groups. Her efforts resulted in ca. 150 original publications and several appointments on (inter)national positions because of her expertise on metrological traceability of test results.
She is vice chair of the International Federation of Clinical Chemistry (IFCC) Scientific Division EC and member of ISO TC 212/ working group 2. She also chairs the European Federation of Laboratory Medicine (EFLM) working group on Test Evaluation. At the national level she is heading the Dutch Calibration 2.000 initiative. Currently, she moved to research on the selection, development and standardization of protein biomarkers using quantitative clinical chemistry proteomics, as a promising alternative for flawed and hardly standardized immunoassays. In that context, she leads the IFCC working group on standardization of serum apolipoproteins by mass spectrometry.