JUL 29, 2020 10:00 AM EDT

Metabolic control of T cell tolerance and antitumor immunity

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Member (Professor), Robert G. Webster Endowed Chair, Department of Immunology, St. Jude Children's Research Hospital
    Biography
      Hongbo Chi, Ph.D. received his Ph.D. from the University of Rochester, and his postdoctoral training from Yale University School of Medicine. In 2007, he started his independent research program at St. Jude Children's Research Hospital, where he is currently a member (professor) in the Department of Immunology, and Robert G. Webster Endowed Chair in Immunology. His research focuses on mechanisms of immune signaling and metabolism, in particular how mTOR and other signaling pathways interplay with metabolic programs in T cell fate decisions. His laboratory has discovered the critical importance of mTOR signaling, metabolism and autophagy in the differentiation and function of effector and regulatory T cells, the control of T cell quiescence and antigen-triggered exit from quiescence, and the regulation of autoimmune and infectious diseases and cancer. His research has also contributed to our understanding of the signaling and metabolic pathways in dendritic cell biology and the crosstalk between innate and adaptive immunity. More recently, his laboratory applies systems biology and immunology approaches, such as proteomics, metabolomics, single cell RNA-sequencing (scRNA-Seq), CRISPR screening and integrative network analysis, to reconstruct metabolic signaling circuits and identify new therapeutic targets in cancer and other immune-mediated diseases.

    Abstract

    Coordination of immune cell metabolic programs with cell fate and state is a fundamental determinant of immune responses. Emerging evidence highlights that the interplay between immune signaling and metabolic programming orchestrates the activation and differentiation of T cells that further impact the outcome of immune responses. In particular, immunometabolism has key roles in shaping the functional fitness of both regulatory and effector T cells in the tumor microenvironment. Here I will discuss our recent findings regarding how mTOR and other signaling pathways bridge nutrient signals and cell metabolic programs to direct T cell priming and function, and the implications in immune tolerance and antitumor immunity. I will also discuss the use of systems immunology and functional genomics approaches including pooled CRISPR screening to investigate metabolic signaling and identify new therapeutic targets in cancer therapy.

     

    Learning Objectives:

    Discover how:

    1. Immunometabolism has key roles in shaping the functional fitness of both regulatory and effector T cells in the tumor microenvironment.

    2. mTOR and other signaling pathways bridge nutrient signals and cell metabolic programs to direct T cell priming and function, and the implications in immune tolerance and antitumor immunity.

    3. The use of systems immunology and functional genomics approaches including pooled CRISPR screening is powerful to explore metabolic signaling and discover new therapeutic targets in cancer therapy.


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