AUG 14, 2019 8:00 AM PDT

The Metagenomics of Dozens of Earth's Cities and One Space Station

Sponsored by: Zymo Research
Speaker
  • Associate Professor/WorldQuant Foundation Research Scholar Physiology and Biophysics/Feil Family Brain and Mind Institute/Institute for Computational Biomedicine, Weill Cornell Medicine
    BIOGRAPHY

Abstract
DATE: August 14, 2019
TIME:  8:00am PDT
 
Infectious disease surveillance and monitoring is critical in settings where disease outbreaks and antibiotic resistance can dramatically impact human health. Rapid and accurate detection of human pathogens between closely related strains and across phylogenetic kingdoms is paramount to mitigate disease outbreaks and to diagnose affected individuals.  Here, we use demonstrate cross-kingdom species detection by simultaneously sequencing DNA from 8 bacteria and 2 fungi in the ZymoBIOMICS control.  We test this on long-read (PacBio, oxford nanopore), short read (Illumina), and linked, long-read (10x Genomics) platforms.  We also show that these standard aliquots can be used for benchmarking a variety of tools and also characterize their epigenetic changes (base modifications).  These standards are now being used internationally as part of a large-scale effort and improving metagenomics use in the clinic, or “precision metagenomics,” as well as for city-scale monitoring of the dynamics of anti-microbial resistance (AMR) with the Metagenomics of Subways and Urban Biomes (MetaSUB) project. 
 
Key Learning Objectives:
  • Measure the differences in accuracy for metagenomics tools
  • Describe the proportion of DNA found in inert surfaces
 
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AUG 14, 2019 8:00 AM PDT

The Metagenomics of Dozens of Earth's Cities and One Space Station

Sponsored by: Zymo Research

Specialty

Molecular Biology

Microbiology

Genomics

Genetics

Molecular Diagnostics

Biotechnology

Infectious Disease

Bioinformatics

Dna Sequencing

Cell Biology

Laboratory Testing

Cancer Research

Dna

Pcr/rt-Pcr/real-Time Pcr

Gene Sequencing

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North America64%

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Job Title

Research Scientist16%

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Facility/Department Manager9%

Medical Laboratory Technician8%

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