NOV 05, 2019 9:00 AM PST

Minicircle DNA: a new material for CAR-T and AAV vector particles - its development and analysis

Sponsored by: SCIEX
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Founder and CEO of PlasmidFactory GmbH&Co. KG
    Biography
      Dr. Martin Schleef studied biology at the Universities of Würzburg and Bielefeld, Germany and holds a diploma in biology and a PhD from the Bielefeld University. He received post-doctoral training from the Institut Pasteur,Paris,France. He joined Qiagen GmbH, Hilden, Germany in 1994, He is founder and CEO of PlasmidFactory GmbH&Co.KG, a prosperous biotech company in Bielefeld, since 2000, and is lecturer at the Bielefeld University.

    Abstract
    DATE:  November 5, 2019
    TIME:  9:00am PT, 12:00pm ET
     
    New results have highlighted the advantages of minicircles over plasmids as they avoid unnecessary bacterial backbone sequences due to higher transfection efficiencies and offer benefits especially in the production of AAV vectors and CAR-T cells.
     
    In this webinar we highlight how the manufacturing process, developed in close collaboration with leading experts in the fields of AAV and CAR-T cell-based therapies, meets the requirements of regulating agencies and leads to high quality grade minicircle DNA. We will then highlight how we use capillary electrophoresis (CE) to fully characterize supercoiled ccc-minicircle DNA helping the development of the manufacturing process and maintenance of product quality.
     
    Learning Objectives:
    • Outline the development and production process of Minicircle DNA for CAR-T cell therapy.
    • Discover the advantages of Minicircles in AAV vector manufacturing.
    • Demonstrate how capillary electrophoresis (CE) helps ensure the quality of Minicircle DNA.

     

    Webinars will be available for unlimited on-demand viewing after live event.
     
    LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

     

     

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