New results have highlighted the advantages of minicircles over plasmids as they avoid unnecessary bacterial backbone sequences due to higher transfection efficiencies and offer benefits especially in the production of AAV vectors and CAR-T cells.

 

In this webinar we highlight how the manufacturing process, developed in close collaboration with leading experts in the fields of AAV and CAR-T cell-based therapies, meets the requirements of regulating agencies and leads to high quality grade minicircle DNA. We will then highlight how we use capillary electrophoresis (CE) to fully characterize supercoiled ccc-minicircle DNA helping the development of the manufacturing process and maintenance of product quality.

 

Learning Objectives: