DEC 09, 2015 8:00 AM PST

Moisture Analysis in Pharma: Expanding Near-Infrared Spectroscopy with Karl Fischer Titration

Sponsored by: Metrohm USA, Metrohm USA
Speakers
  • Technical Application Specialist, Metrohm USA
    Biography
      Joe graduated with a BS in Environmental Chemistry from the college of Environmental Science and Forestry in Syracuse and then later completed an MS in analytical chemistry from Northeastern Illinois after moving to Chicago. Joe joined Metrohm from UOP-Honeywell in 2013 after spending 13 years in the R&D lab (as a big Metrohm fan). Prior to that, Joe worked as a quality assurance/validation chemist at Environmental Standards in PA.
    • Applications Specialist, Metrohm USA
      Biography
        Dr. Keith Freel is an Applications Specialist for Metrohm USA. His undergraduate and graduate work in both engineering and spectroscopy, combined with his time at MetrohmUSA, has seasoned him with over a decade of experience in spectroscopy. In his role with Metrohm, he performs NIR feasibility studies, develops qualitative and quantitative models, leads NIR training courses, and supports Metrohm's partners with their specific applications. He is the go-to person for Chemometrics and NIR method development.

      Abstract

      DATE: December 9, 2015
      TIME: 8am Pacific, 11am Eastern

      Pharmaceutical product quality, effectiveness and shelf life depends significantly on the water content in these products, which makes water determination in pharmaceutical analysis so important.

      Routine Karl Fischer titration is the prescribed technique for measuring residual moisture content to monitor process control, sample specification and optimize freeze-drying processes for lyophilized products. 

      Near-infrared (NIR) analysis offers a number of advantages over traditional instrumental analysis methods including no sample preparation, rapid analysis times and recovery of an intact sample. This technique measures qualitative and quantitative moisture content either inline or at-line reducing over-processing of product and improving production consistency.

      While NIR is a more profitable and productive technique in the long run, quantitative NIR analysis requires prior calibration and validation from reference analytical methods. Karl Fischer titration provides the necessary foundation to build and validate this calibration. Learn how choosing the proper technique and sample handling procedure greatly improves the repeatability and accuracy of Karl Fischer titrations and leads to faster NIR implementation for both lab and in-process measurements.

      Key learning objectives:

      • Understanding the importance of selecting the right KF and sample handling techniques
      • Implementing Near-IR for moisture analysis in lyophilized and other pharmaceutical products
      • Quantifying residual moisture online in the drying process

       Who should attend:

      • Those using Karl Fischer titration for applications in the pharmaceutical industry
      • Anyone who spends time in the lab preparing samples for moisture analysis
      • Anyone facing challenges monitoring and controlling analyses
      • Those who want to discover the benefits of implementing NIR for routine moisture analysis – Saving time, money and ensuring ease of operation.

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