MAY 28, 2014 10:30 AM PDT

Monitoring drugs and medications in pain and addiction patients


Abstract

Guidelines for physicians treating pain patients with chronic opioid therapy recommend the patients be monitored for the presence of their prescribed medications. In addition, it is often recommended that these patients be monitored for the possible presence of non-prescribed medications and drugs. Monitoring patients with substance abuse issues requires a similar testing menu that includes a wide spectrum of prescription medications and illicit agents. Analytical considerations in drug testing are important for health care providers to understand for optimal clinical decision-making. Point of care devices based on immunoassay principles have gained popularity for this type of testing. However, all immunoassays have limited ability to provide the required analytical sensitivity and specificity required for the clinician to make an accurate clinical assessment. Furthermore, the test menus are limited and do not include newer medications. Finally, immunoassay tests are readily deceived by the addition of small amounts of the medication tablet. The current method of choice for providing such testing is liquid chromatography tandem mass spectrometry. Because of its sensitivity and specificity for many drugs, testing can be performed with little sample preparation. Of additional benefit, it is possible to adjust cutoffs to meet clinical needs. Historically urine has been the fluid of choice for drug testing, but oral fluid is being used more frequently as it is an easily obtained witnessed collection. Interpretation of drug testing results should include quantitative evaluation of the inactive as well as the active metabolites of the administered medication.


Objectives
1. Understand why patients on chronic opioid therapy are monitored.
2. Be able to describe the range of drugs encountered
3. Be able to discuss the differnces in specificity betweem immunoassays and mass spectrometry ones
4. Bio, title, BioBe able to describe the detection of drugs in urine and oral fluid


Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
OCT 20, 2021 10:00 AM PDT
C.E. CREDITS
OCT 20, 2021 10:00 AM PDT
Date: October 20, 2021 Time:10:00am (PDT), 1:00pm (EDT) As the prevalence of Diabetes continues to rise in many areas across the globe, healthcare providers continue to look for methods that...
SEP 17, 2021 12:00 PM CST
C.E. CREDITS
SEP 17, 2021 12:00 PM CST
Date: September 16, 2021 Time: 9:00pm (PDT), 12:00am (EDT) 3D cellular models like organoids and spheroids offer an opportunity to better understand complex biology in a physiologically rele...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
OCT 12, 2021 9:00 AM PDT
C.E. CREDITS
OCT 12, 2021 9:00 AM PDT
Date: October 12, 2021 Time: 9:00am (PDT), 12:00pm (EDT) SCIEX’s next-generation Biologics Explorer software is an innovative platform for the comprehensive and deep characterization o...
MAY 28, 2014 10:30 AM PDT

Monitoring drugs and medications in pain and addiction patients


No demographic data is available yet for this event.


Show Resources
Loading Comments...
Show Resources