NOV 09, 2017 09:00 AM PST

Monitoring Pain Management Medications in Pregnancy and the Neonate

C.E. CREDITS: P.A.C.E. CE | Florida CE
Speakers
  • Medical Director, Toxicology and Pharmacogenetics, ARUP Laboratories
    Biography
      Dr. McMillin is a professor of pathology at the University of Utah School of Medicine. She received her PhD in pharmacology and toxicology from the University of Utah and is certified by the American Board of Clinical Chemistry in clinical chemistry and toxicological chemistry. Dr. McMillin is actively involved in professional associations such as the International Association of Therapeutic Drug Monitoring and Clinical Chemistry (IATDMCT), the American Association for Clinical Chemistry (AACC), and the College of American Pathologists (CAP). Her primary interests include detection of neonatal drug exposures, as well as clinical applications and implementation of pharmacogenomics.

    Abstract:

    Acute and chronic pain are often managed with drug therapy, which may include extended use of drug classes such as opioids and benzodiazepines.  Pain does not go away, and may intensify during pregnancy.  A woman who uses drugs (prescribed and/or non-prescribed) during pregnancy may expose her unborn child to compounds that could adversely affect neonatal development, may lead to premature delivery, and may precipitate a characteristic withdrawal syndrome called neonatal abstinence syndrome (NAS).  In the United States, the Centers for Disease Control and Prevention has reported that among 28 states surveyed, the overall incidence of NAS increased by 300% from 1999 to 2013 (https://www.cdc.gov/mmwr/volumes/65/wr/mm6531a2.htm).  A pregnant woman that has a known addiction to opioids may be managed with opioid substitution agents such as buprenorphine or methadone, which may reduce the incidence and severity of NAS.  Nonetheless, treatment of NAS may require several weeks of intensive care for the newborn, as well as extensive follow-up care and social management.  As such, accurate and timely detection of in utero substance exposure is a critical component of pre- and post-natal care and can assure provision of appropriate medical and social services for the newborn, the mother, and the associated caregivers.  Testing biological specimens for drugs is an important tool for detection and confirmation of drug exposure.  This presentation will describe pros and cons of several specimen types used to monitor exposure to medications during pregnancy and after delivery.  Common analytical methods and challenges with interpretation of results will also be discussed.


    Show Resources
    You May Also Like
    SEP 05, 2019 04:00 PM CEST
    C.E. CREDITS
    SEP 05, 2019 04:00 PM CEST
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    JUN 05, 2019 05:00 PM CEST
    C.E. CREDITS
    JUN 05, 2019 05:00 PM CEST
    DATE: June 5, 2019TIME: 8:00am PDT, 11:00am EDT, 5:00pm CEST Eukaryotic cell cultures respond to the most subtle influence. Apart from the risk of contamination, minimal chan...
    AUG 27, 2019 09:00 AM PDT
    C.E. CREDITS
    AUG 27, 2019 09:00 AM PDT
    DATE: August 27, 2019 TIME: 9:00am PDT, 12:00pm EDT Immunotherapies targeting PD-1 or PD-L1 have proven remarkably effective for treating cancer in some patients, with considerabl...
    OCT 02, 2019 11:00 AM PDT
    OCT 02, 2019 11:00 AM PDT
    DATE: October 2, 2019TIME: 11:00am PDT, 2:00pm EDT Ditch the Excel spreadsheets and manage your molecular workflows entirely in your LIMS Achieve configuration of molecular workf...
    JUL 30, 2019 10:00 AM PDT
    C.E. CREDITS
    JUL 30, 2019 10:00 AM PDT
    DATE: July 30, 2019TIME: 10:00am PT/ 1:00pm ET The importance of building a validation structure within your lab cannot be overstated. Once in place, the ability to identify high...
    AUG 15, 2019 09:00 AM PDT
    C.E. CREDITS
    AUG 15, 2019 09:00 AM PDT
    DATE: August 15, 2019TIME: 9:00am PDT, 12:00pm EDT Radiation therapy is a critical tool for the treatment of brain tumors, however, exposure to high doses of ionizing radiation...
    Loading Comments...
    Show Resources