JUN 10, 2021 8:55 AM PDT

Next Level of Interactome: Methods for Discovering Novel Protein-Nucleic Acid Interactions from Complex Samples

  • Henning Urlaub

    Group Leader - Bioanalytical Mass Spectrometry, University Medical Center Göttingen, Germany


Mass spectrometry-based proteomics methods are finding increasing use in structural biology research. Beyond simple interaction networks, information about stable protein-protein, protein-ligand or protein-DNA or RNA complexes help to elucidate the biological functions of proteins and nucleic acids in a wider cellular context. New workflow developments and data processing will be discussed as how protein-RNA or DNA interactions can be detected and localized at the single amino acids.

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