Operation Moonshot: Rapid Translation of a SARS CoV2 LC-MS/MS Test from Research to Routine Use

The Moonshot program was established in the UK by The Department of Health and Social Care to explore novel technologies for the detection of SARS-COV-2. Mass spectrometry was identified as a potential candidate and experts from academia, industry and the National Health Service (NHS) worked in partnership to develop a state-of-the-art targeted proteomic assay, refine the method for use in a routine clinical environment, and validate it to ISO:15189 standards.

Learning Objectives:

1. Demonstration of an LC-MS/MS workflow for the analysis of SARS-CoV-2, with excellent agreement to PCR.

2. Validation of a ready to use SARS-CoV-2 LC-MS Kit, automated on the Andrew Alliance Andrew+ pipetting robot.

3. Differentiation of the SARS-CoV-2 delta variant from previous variants of concern.