AUG 30, 2016 08:00 AM PDT

Optimizing retinal cell differentiation of human pluripotent stem cells for large-scale disease modeling.

  • Associate Professor, ARC Future Fellow, Head, Neuroregeneration Research Unit, Centre for Eye Research Australia, University of Melbourne
      Dr. Pébay is an Australian Research Council Future Fellow. She obtained her PhD in Neurosciences from the University of Paris VI in 2001 and subsequently joined Professor Martin Pera at Monash University to undertake research on human embryonic stem cells (hESCs). She then continued her research in this area at the University of Melbourne where she commenced in 2007. Since 2012, Dr.Pébay has been appointed to both the Centre for Eye Research Australia and The University of Melbourne. More specifically, Dr. Pébay heads research projects on the identification of signaling mechanisms involved in the maintenance of pluripotency, neural differentiation and more recently cardiac and ocular differentiation of pluripotent stem cells and diseased iPSCs. Her long-term research goal is the establishment of well characterized and efficient protocols for maintenance and differentiation of pluripotent stem cells, suitable for drug screening.

    Human induced pluripotent stem cells (iPSCs) are valuable cells for retinal disease modeling, as these cells are of patient origin and can be differentiated into cell types of interest. This presentation will discuss the differentiation of iPSCs into retinal pigment epithelium cells and retinal ganglion cells and their molecular manipulations for modeling degenerative diseases of the retina and optic nerve.

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