OCT 09, 2019 7:30 AM PDT

Keynote Presentation: Pairing protein profiling with drug screens uncovers an effective therapy against high risk leukemia

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Assistant Adjunct Professor in the Department of Pediatrics/Hematology at UCSF
    Biography
      Ernesto Diaz-Flores, PhD, is an Assistant Adjunct Professor in the Department of Pediatrics/Hematology at UCSF. He is an experienced biochemist with a focus on identifying novel therapeutics for high-risk childhood leukemia. Dr. Diaz-Flores obtained his BsC in Biochemistry at the Universidad Complutense (Madrid) and his PhD in molecular biology for his studies of lymphocyte activation at the Universidad Autonoma (Madrid). He came to UCSF for his postdoctoral studies first under the supervision of Dr Kevin Shannon, studying murine models of Kras leukemia and then pursuing a second postdoctoral fellowship in Dr. Mignon Loh's laboratory. Dr Diaz-Flores specializes in identifying novel therapies for children with hypodiploid leukemia. His work combines the study of dysregulated signaling networks, transcriptomics analysis and drug assays. He further validates drugs with therapeutic potential running in vivo preclinical trials using patient derived xenografted models. His latest work has informed a clinical trial for patients with high-risk leukemia

    Abstract

    Acute lymphoblastic leukemia is the most common cancer in children and adolescents. While current treatments have resulted in 85-90% cure, the remaining 10-15% cases represent the leading causes of childhood cancer mortality. This is largely due to specific leukemia subtypes being resistant to treatment. One of these subtypes is hypodiploid B cell leukemia characterized by multiple chromosomal losses. For these patients, treatment options remain limited, and their prognosis is dim.

    Learning Objectives:

    1. How to integrate genomics and proteomics profiling with drug screens to identify potential therapeutic targets

    2. How to move from in vitro to in vivo preclinical studies to inform new clinical trials.

    3. The audience will learn about hypodiploidy: from cytogenetics to prognosis to drug response in the context of leukemia.

     


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