APR 08, 2020 7:30 AM PDT

Keynote Presentation: New Paradigms in moving toward Point-of-Care Cell Therapy Services in the Hospital

Presented at: BioProcessing 2020
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Resident Physician, John Hopkins
    Biography
      Robert Kruse, MD, PhD is a resident physician at Johns Hopkins training in clinical pathology. He received his MD and PhD degrees from Baylor College of Medicine, studying immunotherapy of hepatitis B virus using CAR-T cells. He will pursue a transfusion medicine fellowship at Harvard Medical School.

    Abstract

    Genetically-modified cell therapies are revolutionizing medicine, offering new opportunities to treat cancer patients and potentially many other diseases. The process of producing gene-modified cell therapies, in particular CAR-T cells, derived from patients is very complex, however, restricting widespread use. The current process involves collection of T cells by apheresis, and shipment from the hospital to a centralized manufacturing site, where cells transduced with gene and grown for 2-3 weeks, before returning to the hospital for infusion into the patient. The significant complexity, freeze/thaw cycles, shipments, and delay in getting therapies pose challenges. As an alternative, a point of care cell therapy production within hospitals would obviate the need for shipping and may reduce the time to get therapies to patients. Automated manufacturing machines will be essential in this paradigm, in order to standardize cellular manufacturing across all hospitals and to deliver the same products to patients. A distributed point-of-care paradigm may ultimately provide an avenue to scale cell therapies to more patients and expand into new clinical indications.

    Learning Objectives:

    1. Define the mechanism of cell therapies and their clinical indications

    2. Identify the key bottlenecks in the delivery of cell therapies to patients today

    3. Explain how point of care cell therapy production in hospitals could work


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