SEP 26, 2019 7:30 AM PDT

Keynote Presentation: Phagocytosis, macropinocytosis and the innate immune response; recent advances

Presented at: Cell Biology 2019
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Senior Scientist at The Hospital for Sick Children and Professor of Biochemistry, University of Toronto.
    Biography
      Dr. Sergio Grinstein completed his Ph.D. in 1976 at the Centro de Investigacion, in Mexico City. He then spent two years as a post-doctoral fellow at the Hospital For Sick Children in Toronto, followed by a year in the Department of Biochemistry at the Federal Institute of Technology in Zurich. He is currently working at the Hospital For Sick Children in Toronto, where he was Head of the Programme in Cell Biology from 1987-2007 and has been Professor of Biochemistry at the University of Toronto since 1988. Dr. Grinstein was an International Scholar of the Howard Hughes Medical Institute, a recipient of the Medical Research Council Distinguished Scientist Award and of the Michael Smith Award of the Canadian Institutes for Health Research and is a Fellow of the Royal Society of Canada. He held the Pitblado Chair in Cell Biology at the Hospital for Sick Children from 2000-2015.

    Abstract

    The innate immune response requires continuous surveillance of the environment, and the ability to detect and react to pathogens and danger signals. Phagocytosis –the ingestion of particulate matter ≥0.5 µm in diameter– and macropinocytosis –the gulping of large volumes of extracellular fluid– are key components of innate immunity.  Both processes are complex and elegant, involving receptors and signal transduction, as well as cytoskeletal and membrane remodeling; a compendium of cell biology! These processes are often subverted by viruses, bacteria and fungi that take advantage of the host cells to establish a niche that favors their growth, replication and dissemination. My presentation will consist of a review of basic aspects of phagocytosis and macropinocytosis, followed by two sections describing recent advances in the field that have revealed the involvement of unique cytoskeletal structures (in the case of phagocytosis) and of ion channels (in macropinocytosis).

    Learning objectives:

    1. Understand the stages and functional roles of macropinocytosis and phagocytosis.

    2. Appreciate the key role of phosphoinositides and inorganic ions in signaling and driving the formation and maturation of phagosomes and macropinosomes.


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