NOV 12, 2015 10:30 AM PST

Pharmacogenetics in the Clinical Laboratory: Opportunities and Challenges

Speakers
  • Clinical Chemistry Fellow, Department of Pathology, Johns Hopkins University School of Medicine
    Biography
      Allison Chambliss, PhD is a Clinical Chemistry Fellow in the Department of Pathology at the Johns Hopkins University School of Medicine. She received her B.S. in Chemical Engineering from Virginia Tech and her PhD in Chemical & Biomolecular Engineering from Johns Hopkins University. Allison's current clinical research interests include development of rapid, targeted pharmacogenetics assays and mass spectrometry methods. Her current training areas include operation of the clinical laboratory, quality control and assurance, laboratory management, analytical methodologies, and test interferences.

    Abstract:

    Appropriate dosing of pharmaceuticals is critical to prevent sub-therapeutic efficacy or the occurrence of adverse events. However, genetic variability may significantly influence an individual’s response to a therapeutic agent. Wide genetic variability has been observed in a number of drug-metabolizing enzymes, which are responsible for the activation or inactivation of numerous drug classes. Targeted identification of specific genetic variants may assist in providing the optimal drug at the optimal dose to the correct patient. With the aid of case studies, this presentation will describe representative genetic variants that are known to influence the metabolism of commonly-prescribed medications. The presentation will also explore the current analytical platforms and challenges associated with implementing pharmacogenetic testing in a clinical laboratory environment.

    Learning Objectives:

    1. Describe the role of genetics in the metabolism of commonly-prescribed medications.
    2. Relate genotypes of frequent drug-metabolizing variants to drug activity.
    3. Discuss the advantages and disadvantages of current approaches to pharmacogenetic testing.


    Show Resources
    You May Also Like
    SEP 05, 2019 04:00 PM CEST
    C.E. CREDITS
    SEP 05, 2019 04:00 PM CEST
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    MAY 16, 2019 04:00 PM CEST
    C.E. CREDITS
    MAY 16, 2019 04:00 PM CEST
    DATE: May 16, 2019TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST The emergence of NGS is revolutionizing the microbiological sciences and transforming medicine. Deep sequencing has...
    AUG 27, 2019 09:00 AM PDT
    C.E. CREDITS
    AUG 27, 2019 09:00 AM PDT
    DATE: August 27, 2019 TIME: 9:00am PDT, 12:00pm EDT Immunotherapies targeting PD-1 or PD-L1 have proven remarkably effective for treating cancer in some patients, with considerabl...
    OCT 02, 2019 11:00 AM PDT
    OCT 02, 2019 11:00 AM PDT
    DATE: October 2, 2019TIME: 11:00am PDT, 2:00pm EDT Ditch the Excel spreadsheets and manage your molecular workflows entirely in your LIMS Achieve configuration of molecular workf...
    JUN 05, 2019 05:00 PM CEST
    C.E. CREDITS
    JUN 05, 2019 05:00 PM CEST
    DATE: June 5, 2019TIME: 8:00am PDT, 11:00am EDT, 5:00pm CEST Eukaryotic cell cultures respond to the most subtle influence. Apart from the risk of contamination, minimal chan...
    JUL 30, 2019 10:00 AM PDT
    C.E. CREDITS
    JUL 30, 2019 10:00 AM PDT
    DATE: July 30, 2019TIME: 10:00am PT/ 1:00pm ET The importance of building a validation structure within your lab cannot be overstated. Once in place, the ability to identify high...
    Loading Comments...
    Show Resources