OCT 09, 2019 10:30 AM PDT

A practical guide for multiplexed ion beam imaging to reveal tumor immunobiology

Sponsored by: IONpath
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Sr.Staff Scientist/LSRP3, Stanford University
    Biography
      Prior to Stanford Selena worked as a Research Scientist within the Immunotherapy Platform, led by Nobel laureate Professor James Allison at MD Anderson Cancer Center, where she analyzed and interpreted data for immunotherapy clinical trials and implemented an imaging technology to study the immune landscape in metastatic renal cell carcinoma. As a Sr. Scientist at Stanford University, Selena is interested in investigating the role of glioma infiltrating macrophages in disease pathogenesis. More specifically, she wants to understand how cell-cell communication affects macrophage cell types and states in Glioblastoma in order to accelerate future immunotherapy strategies. Concomitantly Selena is overseeing and supporting Dr. Angelo's research collaborations derived from the implementation of the MIBI technology in diseased tissue.

    Abstract

    MIBI is a powerful platform for identifying and analyzing multiple antigens in formalin-fixed paraffin-embedded tissues. This multiplexed methodology permits the identification of 40+ proteins at the same time in one single tissue section, with the ability to study various cell populations and their spatial distribution in different tissue specimens, including core needle biopsies, tissue microarrays, and whole sections at imaging resolution approaching 200nm.
    During this presentation, we will show examples of cancer research using MIBI technology and provide an overview of the panel design and validation.
     
    Learning Objectives:

    1. Learn how MIBI technology is used in cancer research   

    2. Learn how to design and optimize a MIBI panel for cancer research


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