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DEC 11, 2014 7:00 AM PST

Preparing Your Clinical Laboratory for High Throughput Buccal Swab DNA Purification

Speaker
  • Director of Technology at Interleukin Geneticsaker
    Biography
      René Oda serves as the Director of Technology of Interleukin Genetics, where he uses his expertise in biochemistry and robotics to continually innovate the technology and processes of a high throughput, CLIA certified clinical laboratory. His continual drive towards scalable and robust methods has led to a clinical sample preparation process capable of genotyping millions of patients per year. After early formative experiences at MIT and the Whitehead Institute, he developed automated genotyping chemistries and applications at biomedical systems maker Beckman Coulter that enabled scalable processing of over 60,000 samples per day. After progressing through roles in development, project management, and strategic marketing, he earned Beckman Coulter's highest honor for outstanding achievement, the Circle of Excellence, and later founded his own biotechnology consulting firm to guide companies in developing high throughput genetic analysis laboratories. He joined Interleukin Genetics in 2011 to help make large scale genetic testing attainable for chronic diseases such as periodontitis, which affects over 64 million adults in the US alone.

    Abstract

     

    Successfully performing high throughput DNA purification in a clinical laboratory requires a robust automated method to handle the wide ranges in DNA quality and quantity found with patient buccal swabs, and to avoid the difficulties of sample recollection. Adopting a single, scalable method ensures stable workflow with consistent patient report turnaround time, even during spikes in incoming sample numbers, and greatly simplifies the CLIA regulated validation process. A single Biomek FX workstation configured with Beckman Coulter’s DNAdvance magnetic bead method enables the purification of approximately 2000 samples during an 8 hour shift with a combined 99.8% success rate per patient, while protecting laboratory personnel from infectious agent exposure and repetitive stress injuries. Special considerations and solutions for clinical environments will be presented that also apply to high throughput research laboratories. 

    Learning Objectives:

    • Learn how a single Biomek FX workstation configured with Beckman Coulter’s DNAdvance magnetic bead method enables the purification of approximately 2000 samples during an 8 hour shift with a combined 99.8% success rate per patient, while protecting laboratory personnel from infectious agent exposure and repetitive stress injuries
    • Learn about special considerations and solutions for clinical environments that also apply to high throughput research laboratories

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