FEB 23, 2021 8:00 AM PST

Quantitation of free light chains in serum and the need for standardization

Sponsored by: Binding Site
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Attending Clinical Chemist in the Department of Laboratory Medicine at Memorial Sloan Kettering Cancer Center
    Biography
      Dr. Kazunori Murata received his PhD from the Johns Hopkins University and completed his fellowship at Mayo Clinic. He is board certified in Clinical Chemistry. Currently, Dr. Murata is an Attending Clinical Chemist in the Department of Laboratory Medicine at Memorial Sloan Kettering Cancer Center. As laboratory director, Dr. Murata is responsible for the management and oversight of the clinical chemistry laboratories and consults with clinicians in selecting appropriate tests and interpreting the results of these tests.
      Dr. Murata's research interests are focused on novel biomarkers of disease. Significant amount of his time is dedicated to the development and validation of new diagnostic assays and to conducting clinical research to evaluate the diagnostic utility of these tests with the goal of bringing new tests from the research bench into routine clinical use.

    Abstract
    Date:  February 23, 2021
    Time: 8:00am (PST),  11:00am (EST)
     
    The analysis of serum free light chains (FLC) is now standard of care in the screening, diagnosis, and monitoring of patients suspected of/having multiple myeloma (MM) or other monoclonal gammopathies (MG). Recently, a new FLC immunoassay has become available from Diazyme. The objectives of our study were to analytically validate the Diazyme assay and to determine clinical interchangeability of two different FLC assays in patients with MG and in a presumed healthy population.
     
    Learning Objectives
    • Describe the serum free light chain assay and its role in the screening, diagnosis, and monitoring of patients with multiple myeloma
    • List different methods by which free light chains are quantitated
    • Identify issues which should be considered when switching free light chain assay
     
     
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