Attending Clinical Chemist in the Department of Laboratory Medicine at Memorial Sloan Kettering Cancer Center
BIOGRAPHY
FEB 23, 2021 8:00 AM PST
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Quantitation of free light chains in serum and the need for standardization
Speaker
Abstract
Date: February 23, 2021
Time: 8:00am (PST), 11:00am (EST)
The analysis of serum free light chains (FLC) is now standard of care in the screening, diagnosis, and monitoring of patients suspected of/having multiple myeloma (MM) or other monoclonal gammopathies (MG). Recently, a new FLC immunoassay has become available from Diazyme. The objectives of our study were to analytically validate the Diazyme assay and to determine clinical interchangeability of two different FLC assays in patients with MG and in a presumed healthy population.
Learning Objectives
- Describe the serum free light chain assay and its role in the screening, diagnosis, and monitoring of patients with multiple myeloma
- List different methods by which free light chains are quantitated
- Identify issues which should be considered when switching free light chain assay
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