JUN 29, 2018 08:00 AM PDT

Quantitation and profiling metabolomics and translation to clinical analysis

SPONSORED BY: Agilent
C.E. CREDITS: P.A.C.E. CE | Florida CE
Speakers
  • Associate Professor, University of Florida
    Biography
      Dr. Garrett received his undergraduate degree from the University of Georgia in Chemistry graduating Summa Cum Laude with Highest Honors (1999). As an undergraduate, he worked in the lab of Dr. I. Jonathan Amster on the characterization of bacterial proteins using MALDI-TOF completing an undergraduate honors thesis entitle "Improved methods for on-probe cleanup of unpurified protein samples for MALDI time-of-flight mass spectrometry". He received his PhD in 2006 from the University of Florida working under the direction of Dr. Richard A. Yost. As a graduate student, he developed the first imaging mass spectrometry based on ion trap instrumentation through a partnership with Thermo and studied the disposition of phospholipids in brain tissue. His work involved the characterization of phospholipids using tandem mass spectrometry and described the need for tandem mass spectrometry to both separate and identify this complex lipids species directly from tissue. As a graduate student, he received a Grinter Fellowship, a Proctor & Gamble award for excellence in graduate research, the Baites-Laitnen award, and the Crow-Stasch award for excellence in publication. Finally, his publication entitled "Imaging mass spectrometry with a new intermediate-pressure MALDI linear ion trap mass spectrometer" received the best applied graduate student paper for the Internal Journal of Mass Spectrometry. He is currently an Associate Professor in the Department of Pathology, where he is also the Director of high throughput metabolomics, for the Southeast Center for Integrated Metabolomics and conducts research in the application of metabolomics to disease diagnosis and clinical diagnostics. Prof Garrett is the author of over 60 publications and is an Editorial Board for Clinical Mass Spectrometry. His current interest are in the application of direct tissue analysis approaches as well as the use of high resolution mass spectrometry in metabolomics and routine diagnostics.

    Abstract:

    DATE: June 29, 2018

    TIME: 8:00AM PDT

    Measurement of these metabolites represents the digital readout of health.  A key aspect of metabolomics is the utilization of high resolution mass spectrometric approaches to detect and identify metabolites from biological fluids and tissues.  The use of multi-analyte analyses as well as high resolution mass spectrometric approaches has the potential to transform clinical diagnostics for the next generation. This presentation will discuss profiling and quantitative metabolomics techniques such as traditional LC-MS based approaches and new methods that utilize direction analysis approaches.

    Learning Objectives:

    • Demonstrate the use of multianalyte metabolomic panels in clinical research
    • Discuss the application of high resolution mass spectrometry approaches to metabolomics
    • Understand the utilization of bioinformatic tools for interpreting results. 

     

     

     

     

    For Research Use Only. Not for use in diagnostic procedures.


    Show Resources
    You May Also Like
    SEP 05, 2019 04:00 PM CEST
    C.E. CREDITS
    SEP 05, 2019 04:00 PM CEST
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    MAY 16, 2019 04:00 PM CEST
    C.E. CREDITS
    MAY 16, 2019 04:00 PM CEST
    DATE: May 16, 2019TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST The emergence of NGS is revolutionizing the microbiological sciences and transforming medicine. Deep sequencing has...
    AUG 27, 2019 09:00 AM PDT
    C.E. CREDITS
    AUG 27, 2019 09:00 AM PDT
    DATE: August 27, 2019 TIME: 9:00am PDT, 12:00pm EDT Immunotherapies targeting PD-1 or PD-L1 have proven remarkably effective for treating cancer in some patients, with considerabl...
    JUN 05, 2019 05:00 PM CEST
    C.E. CREDITS
    JUN 05, 2019 05:00 PM CEST
    DATE: June 5, 2019TIME: 8:00am PDT, 11:00am EDT, 5:00pm CEST Eukaryotic cell cultures respond to the most subtle influence. Apart from the risk of contamination, minimal chan...
    AUG 13, 2019 09:00 AM PDT
    C.E. CREDITS
    AUG 13, 2019 09:00 AM PDT
    DATE: August 13, 2019TIME: 9:00am PT, 12:00pm ET, 5:00pm BST Molecular complexes are major constituents of cells, hence unraveling their mechanisms is key to fuller comprehension of c...
    OCT 02, 2019 11:00 AM PDT
    OCT 02, 2019 11:00 AM PDT
    DATE: October 2, 2019TIME: 11:00am PDT, 2:00pm EDT Ditch the Excel spreadsheets and manage your molecular workflows entirely in your LIMS Achieve configuration of molecular workf...
    Loading Comments...
    Show Resources