JUN 29, 2018 8:00 AM PDT

Quantitation and profiling metabolomics and translation to clinical analysis

Sponsored by: Agilent
C.E. Credits: P.A.C.E. CE Florida CE
Speakers
  • Associate Professor, University of Florida
    Biography
      Dr. Garrett received his undergraduate degree from the University of Georgia in Chemistry graduating Summa Cum Laude with Highest Honors (1999). As an undergraduate, he worked in the lab of Dr. I. Jonathan Amster on the characterization of bacterial proteins using MALDI-TOF completing an undergraduate honors thesis entitle "Improved methods for on-probe cleanup of unpurified protein samples for MALDI time-of-flight mass spectrometry". He received his PhD in 2006 from the University of Florida working under the direction of Dr. Richard A. Yost. As a graduate student, he developed the first imaging mass spectrometry based on ion trap instrumentation through a partnership with Thermo and studied the disposition of phospholipids in brain tissue. His work involved the characterization of phospholipids using tandem mass spectrometry and described the need for tandem mass spectrometry to both separate and identify this complex lipids species directly from tissue. As a graduate student, he received a Grinter Fellowship, a Proctor & Gamble award for excellence in graduate research, the Baites-Laitnen award, and the Crow-Stasch award for excellence in publication. Finally, his publication entitled "Imaging mass spectrometry with a new intermediate-pressure MALDI linear ion trap mass spectrometer" received the best applied graduate student paper for the Internal Journal of Mass Spectrometry. He is currently an Associate Professor in the Department of Pathology, where he is also the Director of high throughput metabolomics, for the Southeast Center for Integrated Metabolomics and conducts research in the application of metabolomics to disease diagnosis and clinical diagnostics. Prof Garrett is the author of over 60 publications and is an Editorial Board for Clinical Mass Spectrometry. His current interest are in the application of direct tissue analysis approaches as well as the use of high resolution mass spectrometry in metabolomics and routine diagnostics.

    Abstract:

    DATE: June 29, 2018

    TIME: 8:00AM PDT

    Measurement of these metabolites represents the digital readout of health.  A key aspect of metabolomics is the utilization of high resolution mass spectrometric approaches to detect and identify metabolites from biological fluids and tissues.  The use of multi-analyte analyses as well as high resolution mass spectrometric approaches has the potential to transform clinical diagnostics for the next generation. This presentation will discuss profiling and quantitative metabolomics techniques such as traditional LC-MS based approaches and new methods that utilize direction analysis approaches.

    Learning Objectives:

    • Demonstrate the use of multianalyte metabolomic panels in clinical research
    • Discuss the application of high resolution mass spectrometry approaches to metabolomics
    • Understand the utilization of bioinformatic tools for interpreting results. 

     

     

     

     

    For Research Use Only. Not for use in diagnostic procedures.


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