Imaging-based techniques have traditionally been restricted to the diagnosis and staging of cancer. But technological advances are moving imaging modalities into the heart of patient care. Imaging can address a critical barrier in precision medicine as solid tumors can be spatial and temporal heterogeneous, and the standard approach to tumor sampling, often invasive needle biopsy, is unable to fully capture the spatial state of the tumor. Image-based phenotyping, which represents quantification of tumor phenotype on medical imaging, is a promising development for precision medicine. Medical imaging can provide a comprehensive macroscopic picture of tumor phenotype and its environment, ideally suited to quantifying the development of tumor phenotype before, during, and after treatment. As a noninvasive technology, medical imaging can be performed at low risk and inconvenience to the patient. Radiomics can quantify this phenotype using advanced data characterization algorithms that can be used to develop biomarkers which complement those derived from biopsies. The ultimate goal of radiomics is to improve precision medicine strategies by allowing clinicians to monitor disease in real time as patients move through treatment. In this talk, Dr. Aerts will discuss recent developments from his group and collaborators performing research at the intersection of radiology and bioinformatics. Also, he will discuss recent work of building a computational image analysis system to extract a rich radiomics set and use these features to build prognostic radiomics signatures. The presentation will conclude with a discussion of future work on building integrative systems incorporating both molecular and phenotypic data to improve cancer therapies.