SEP 26, 2019 6:00 AM PDT

The reciprocal relationship between cytokine dysregulation and binge alcohol consumption

Presented at: Cell Biology 2019
Speaker

Abstract

Neuroinflammation has been implicated as a factor in alcohol-induced neurodegeneration, but the role of the neuroimmune system in alcohol consumption has only recently come to the forefront. The drinking in the dark paradigm (DID) is an alcohol use disorder model that is uniquely suited to study the consummatory mechanisms of binge drinking. Our recent work has characterized the neuroimmune response following ethanol consumption in the DID. Our results indicate that a history of binge-like ethanol drinking promotes a proinflammatory cytokine response in the amygdala and hippocampus. Importantly, direct administration of anti-inflammatory cytokines can reduce ethanol consumption. These findings highlight the reciprocal relationship between alcohol abuse and the neuroimmune response. Alcohol misuse dysregulates cytokine concentrations but manipulating the neuroimmune response may curb excessive consumption.

Learning Objectives:

1. Understand that binge drinking can alter neuroimmune cells and function
2. Describe how manipulation of cytokines reduces binge drinking


Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
JUL 15, 2021 9:00 AM PDT
JUL 15, 2021 9:00 AM PDT
Date: July 15, 2021 Time: 9:00am (PDT), 12:00pm (EDT) The Pisces workflow robust, easy-to-use, end-to-end multi-omics solution for highly multiplexed targeted Spatial RNA analysis. VeranomeB...
JUL 15, 2021 8:00 AM PDT
C.E. CREDITS
JUL 15, 2021 8:00 AM PDT
Date: July 15, 2021 Time: 8:00am (PDT), 11:00am (EDT) High dimensional full spectrum flow cytometry grants unprecedented access to previously unattainable parameters in cellular biology. Flu...
JUN 24, 2021 10:00 AM PDT
C.E. CREDITS
JUN 24, 2021 10:00 AM PDT
Date: June 24, 2021 Time: 10:00am PDT The Chan Zuckerberg Initiative (CZI) was founded to help solve some of society’s toughest challenges— from eradicating disease and improving...
SEP 26, 2019 6:00 AM PDT

The reciprocal relationship between cytokine dysregulation and binge alcohol consumption

Presented at: Cell Biology 2019

Specialty

Laboratory Testing

Clinical Chemistry

Immunology

Cell Biology

Clinical Research

Cell Culture

Microbiology

Infectious Disease

Animal Research

Cancer Diagnostics

Oncology

Biomarkers

Diagnostics

Molecular Biology

Pathology

Geography

North America75%

Asia13%

Europe13%

Registration Source

Website Visitors100%

Job Title

Medical Laboratory Technician33%

Clinical Laboratory Scientist17%

Educator/Faculty17%

Research Scientist17%

Scientist17%

Organization

Academic Institution38%

Hospital25%

Research Institute13%

Clinical Laboratory13%

Pharmaceutical Company13%


Show Resources
Loading Comments...
Show Resources