SEP 26, 2019 06:00 AM PDT

The reciprocal relationship between cytokine dysregulation and binge alcohol consumption

Presented At Cell Biology 2019
Speakers
  • Assistant Professor, Department of Biology, North Carolina Central University
    Biography
      Dr. Marshall is an Assistant Professor in the department of Biological and Biomedical Sciences at North Carolina Central University in Durham, NC. He was previously in the Basic Pharmaceutical Science Department in High Point University's Fred Wilson School of Pharmacy. He received his undergraduate degree from the University of Florida and his doctorate in pharmaceutical sciences from the University of Kentucky. Throughout his academic career, his research has focused on how alcohol abuse fundamentally changes the brain increasing the susceptibility for addiction.

    Abstract:

    Neuroinflammation has been implicated as a factor in alcohol-induced neurodegeneration, but the role of the neuroimmune system in alcohol consumption has only recently come to the forefront. The drinking in the dark paradigm (DID) is an alcohol use disorder model that is uniquely suited to study the consummatory mechanisms of binge drinking. Our recent work has characterized the neuroimmune response following ethanol consumption in the DID. Our results indicate that a history of binge-like ethanol drinking promotes a proinflammatory cytokine response in the amygdala and hippocampus. Importantly, direct administration of anti-inflammatory cytokines can reduce ethanol consumption. These findings highlight the reciprocal relationship between alcohol abuse and the neuroimmune response. Alcohol misuse dysregulates cytokine concentrations but manipulating the neuroimmune response may curb excessive consumption.

    Learning Objectives:

    1. Understand that binge drinking can alter neuroimmune cells and function
    2. Describe how manipulation of cytokines reduces binge drinking


    Show Resources
    You May Also Like
    NOV 18, 2019 07:00 AM PST
    C.E. CREDITS
    NOV 18, 2019 07:00 AM PST
    DATE: November 18, 2019TIME: 7:00am PST, 11:00am EST, 4:00pm CEWT How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop th...
    DEC 10, 2019 09:00 AM PST
    C.E. CREDITS
    DEC 10, 2019 09:00 AM PST
    DATE: December 10, 2019TIME: 9:00am PST, 12:00pm EST A major limitation in the ex vivo expansion of harvested human hematopoietic stem-progenitor cells (HSPCs) is the rapid dif...
    AUG 27, 2019 09:00 AM PDT
    C.E. CREDITS
    AUG 27, 2019 09:00 AM PDT
    DATE: August 27, 2019 TIME: 9:00am PDT, 12:00pm EDT Immunotherapies targeting PD-1 or PD-L1 have proven remarkably effective for treating cancer in some patients, with considerabl...
    JUN 19, 2019 10:00 AM PDT
    JUN 19, 2019 10:00 AM PDT
    DATE: June 19, 2019TIME: 10:00am PDT, 1:00pm EDT As we develop new methods to create more biologically relevant models for research in understanding disease etiology and in...
    AUG 13, 2019 09:00 AM PDT
    C.E. CREDITS
    AUG 13, 2019 09:00 AM PDT
    DATE: August 13, 2019TIME: 9:00am PT, 12:00pm ET, 5:00pm BST Molecular complexes are major constituents of cells, hence unraveling their mechanisms is key to fuller comprehension of c...
    SEP 12, 2019 08:00 AM PDT
    C.E. CREDITS
    SEP 12, 2019 08:00 AM PDT
    DATE: September 12, 2019TIME: 8:00am PDTIn the upcoming era of personalized medicine, there is a growing need for the development of rapid, sensitive, precise and accurate analysis of t...
    Loading Comments...
    Show Resources
    Attendees