MAY 14, 2015 12:00 PM PDT

Regulation of mRNA translation by ribosomes

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  • Senior Vice President, Chief Scientific Officer, Promosome, Adjunct Associate Professor, The Scripps Research Institute
      Dr. Mauro received his Ph.D. from McGill University in Canada and his post-doctoral training at the Rockefeller University. At the Scripps Research Institute, Dr. Mauro established a laboratory focused on understanding fundamental mechanisms of translation initiation. These studies provided the first demonstration of mRNA-rRNA base-pairing as a translation initiation mechanism in eukaryotes and led to the identification of cis-regulatory elements in mRNAs, including translation enhancing elements. Dr. Mauro cofounded Promosome, a biotechnology company that uses technologies pioneered in his laboratory as the basis for protein expression platforms and for expression of hard-to-express proteins with significant therapeutic or industrial value.


    Over the past few years, evidence has been accumulating to indicate that ribosomal subunits are not simply tape-heads that decode mRNA sequences into polypeptide chains, but that they also play an active role in regulating the expression of some mRNAs via specific interactions. In mammals, the 18S rRNA of 40S ribosomal subunits is a key component in mediating these interactions. Our development of a synthetic 18S rRNA expression system enables systematic analysis of this ribosomal component. This talk will review this exciting new field, discuss how modulation of rRNA is being used for analysis of natural ribosomal function, and explore how this approach opens up possibilities for modifying and extending ribosomal function. Learning Objectives: 1. Define basic principles of mRNA translation 2. Classify different mechanisms of translation regulation

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