NOV 11, 2015 10:30 AM PST

Reliability of LDL cholesterol: How low can we go and when are we fooling ourselves?

Speakers
  • Co-Director, Cardiovascular Laboratory Medicine, Mayo Clinic
    Biography
      Dr. Meeusen received a PhD from the University of Wisconsin studying inorganic biochemistry. After graduate school he spent three years as a post-doctoral research fellow supporting Mayo Medical Laboratories esoteric test development. Dr. Meeusen's research interests include lipid and lipoprotein testing and he is currently co-director of Cardiovascular Laboratory Medicine at Mayo Clinic.

    Abstract:

    Aggressive low-density lipoprotein cholesterol (LDL-C) lowering strategies are recommended for prevention of cardiovascular events in high-risk populations. Guidelines recommend a 30-50% reduction in at risk patients even when LDL-C concentrations are between 70 – 130 mg/dL (1.8 – 3.4 mmol/L). Novel PCSK9 inhibitors reduce LDL-C well below previously attainable levels. Calculation of LDL-C by the Friedewald equation is the primary laboratory method for routine LDL-C measurement. However, no recommendations have addressed the appropriate lower reportable limit for calculated LDL-C. This presentation will cover recently published data regarding the accuracy and precision of calculated LDL-C values <130 mg/dL (3.4 mmol/L).


    Show Resources
    You May Also Like
    MAY 22, 2018 08:00 AM PDT
    C.E. CREDITS
    MAY 22, 2018 08:00 AM PDT
    DATE: May 22, 2018TIME: 08:00AM PDT The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that...
    MAY 24, 2018 09:30 AM PDT
    C.E. CREDITS
    MAY 24, 2018 09:30 AM PDT
    DATE: May 24, 2018 TIME: 9:30PM PDT The current gold standard in in vitro pre-clinical cancer treatment screening remain cell lines,...
    MAY 03, 2018 11:00 AM PDT
    MAY 03, 2018 11:00 AM PDT
    DATE: May 3, 2018TIME: 11:00AM PDT, 2:00PM EDTWhile stress is one of the leading causes of neuropsychiatric disorders, the molecular underpinnings of how stress induces alterations in b...
    JUN 26, 2018 06:00 AM PDT
    C.E. CREDITS
    JUN 26, 2018 06:00 AM PDT
    Date: June 26, 2018Time: 6:00 a.m. PDT, 9:00 a.m. EDT, 1500 CEST Today’s hematology analyzers employ various methods for enumerating platelets. These methods include: e...
    JUN 20, 2018 10:00 AM EDT
    C.E. CREDITS
    JUN 20, 2018 10:00 AM EDT
    DATE: June 20, 2018TIME: 07:00AM PDT, 10:00AM EDTIntroducing GE’s New Lyo-StableTM service. Sepsis is one of the top challenges facing hospitals in terms of clinical outcomes...
    APR 27, 2018 10:00 AM PDT
    C.E. CREDITS
    APR 27, 2018 10:00 AM PDT
    DATE: April 27, 2018TIME: 10:00am PST, 1:00pm ESTGlioblastoma (GBM) and Medulloblastoma (MB) are the most common adult and paediatric brain tumours, both of which can have devastating c...
    Loading Comments...