NOV 11, 2015 10:30 AM PST

Reliability of LDL cholesterol: How low can we go and when are we fooling ourselves?

Speaker
  • Co-Director, Cardiovascular Laboratory Medicine, Mayo Clinic
    Biography
      Dr. Meeusen received a PhD from the University of Wisconsin studying inorganic biochemistry. After graduate school he spent three years as a post-doctoral research fellow supporting Mayo Medical Laboratories esoteric test development. Dr. Meeusen's research interests include lipid and lipoprotein testing and he is currently co-director of Cardiovascular Laboratory Medicine at Mayo Clinic.

    Abstract

    Aggressive low-density lipoprotein cholesterol (LDL-C) lowering strategies are recommended for prevention of cardiovascular events in high-risk populations. Guidelines recommend a 30-50% reduction in at risk patients even when LDL-C concentrations are between 70 – 130 mg/dL (1.8 – 3.4 mmol/L). Novel PCSK9 inhibitors reduce LDL-C well below previously attainable levels. Calculation of LDL-C by the Friedewald equation is the primary laboratory method for routine LDL-C measurement. However, no recommendations have addressed the appropriate lower reportable limit for calculated LDL-C. This presentation will cover recently published data regarding the accuracy and precision of calculated LDL-C values <130 mg/dL (3.4 mmol/L).


    Show Resources
    You May Also Like
    APR 07, 2020 8:00 AM PDT
    C.E. CREDITS
    APR 07, 2020 8:00 AM PDT
    DATE: April 7, 2020 TIME: 8:00am PT, 11:00am ET This webinar sets out to establish why quality control is key to robust, reliable, reproducible science. We will look at best practice criteri...
    FEB 26, 2020 9:00 AM PST
    C.E. CREDITS
    FEB 26, 2020 9:00 AM PST
    DATE: February 26, 2020 TIME: 9:00am PST 3D cell culture and analysis and the study of organoids and spheroids are becoming more prevalent as a research method in publications as traditional...
    JAN 23, 2020 9:00 AM PST
    C.E. CREDITS
    JAN 23, 2020 9:00 AM PST
    DATE: January 23, 2020 TIME: 9:00am PST, 12:00pm EST...
    FEB 19, 2020 11:00 AM PST
    C.E. CREDITS
    FEB 19, 2020 11:00 AM PST
    DATE: February 19, 2020TIME: 11:00am PST, 2:00pm EST...
    DEC 05, 2019 5:00 AM PST
    C.E. CREDITS
    DEC 05, 2019 5:00 AM PST
    DATE: December 5, 2019TIME: 5:00am PST, 8:00am EST The diagnosis of an active infection by the hepatitis B virus (HBV) relies on testing for the HBV surface antigen (HBsAg). Ov...
    JUN 09, 2020 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    JUN 09, 2020 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: June 9, 2020 TIME: 10:00am PT, 1:00pm ET The presentation will first discuss sepsis as a disease and then explain the importance of performing diagnostic tests in the clinical labora...
    Loading Comments...
    Show Resources