MAY 10, 2013 09:00 AM PDT

Renin: Clinical Utility of Renin Measurement in Hypertension

SPONSORED BY: DiaSorin, DiaSorin
Speakers
  • Assistant Professor of Medicine at Harvard Medical School and Associate Physician at Brigham and Women's Hospital, Division of Endocrinology
    Biography
      Dr. Williams is an Assistant Professor of Medicine at Harvard Medical School and Associate Physician at Brigham and Women's Hospital, Division of Endocrinology, Diabetes, and Hypertension.  He has dedicated his research efforts to unravelling the intricate relationship between genetics and environment with respect to individual susceptibility to cardiometabolic disease.  He has over 40 original publications describing the physiologic and pathologic interplay of renin-angiotensin-aldosterone system activity and dietary salt intake in hypertension, insulin resistance, heart disease, and obesity.  His work is funded through National Institutes of Health, industry, and private foundation support.
       
      Dr. Williams is an active program developer, course director, and mentor for the Harvard Medical School's Scholars in Clinical Research Program, which is a Master's degree granting program designed to train the upcoming generation of patient-oriented physician scientists.  He is also an Associate Editor of the journal Metabolism, and serves on the Board of Directors for the Association for Patient-oriented Research and for the Association for Clinical and Translational Science.

    Abstract:

     

    Measurement of renin and its activity is increasingly used in the evaluation of circulatory function. This is primarily driven by a higher than previously realized prevalence of primary hyperaldosteronism. Renin measurement is also useful in evaluation of adrenal insufficiency, hypertension with hypokalemia, and assessment of suspected renin hypofunction.  Renin measurement in the assessment of renovascular causes of hypertension has fallen out of favor due to poor predictive capacity in most situations.  Measurement of renin typically occurs via two means.  Plasma renin activity provides a measure of enzymatic performance by calculating the rate of angiotensin I formation by renin.  Alternatively, renin can be directly measured by assessing the mass of renin in concentration.  Physiologic conditions are important modifiers of renin activity. These include body posture, dietary salt intake, diurnal variation, age, race, renal disease, and confounding medications.  As renin determination becomes more widely used in clinical practice, a solid understanding of assay limitations and the host of factors that influence renin activity will be required to properly interpret results.

     


    Show Resources
    You May Also Like
    JUN 05, 2019 05:00 PM CEST
    C.E. CREDITS
    JUN 05, 2019 05:00 PM CEST
    DATE: June 5, 2019TIME: 8:00am PDT, 11:00am EDT, 5:00pm CEST Eukaryotic cell cultures respond to the most subtle influence. Apart from the risk of contamination, minimal chan...
    AUG 27, 2019 09:00 AM PDT
    C.E. CREDITS
    AUG 27, 2019 09:00 AM PDT
    DATE: August 27, 2019 TIME: 9:00am PDT, 12:00pm EDT Immunotherapies targeting PD-1 or PD-L1 have proven remarkably effective for treating cancer in some patients, with considerabl...
    MAY 16, 2019 04:00 PM CEST
    C.E. CREDITS
    MAY 16, 2019 04:00 PM CEST
    DATE: May 16, 2019TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST The emergence of NGS is revolutionizing the microbiological sciences and transforming medicine. Deep sequencing has...
    JUN 18, 2019 04:00 PM CEST
    C.E. CREDITS
    JUN 18, 2019 04:00 PM CEST
    DATE: June 18, 2019TIME: 7:00am PDT, 10:00 EDT, 4:00pm CET PSCs represent an important tool in a wide range of applications, including basic research, disease modeling, drug...
    SEP 05, 2019 04:00 PM CEST
    C.E. CREDITS
    SEP 05, 2019 04:00 PM CEST
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    JUL 30, 2019 10:00 AM PDT
    C.E. CREDITS
    JUL 30, 2019 10:00 AM PDT
    DATE: July 30, 2019TIME: 10:00am PT/ 1:00pm ET The importance of building a validation structure within your lab cannot be overstated. Once in place, the ability to identify high...
    Loading Comments...
    Show Resources
    Attendees