MENU

Higher Resolution Electrodes Improve Our Understanding Human Brain, Cognition, and Neurological Pathologies

Presented at: Neuroscience 2022
C.E. Credits: P.A.C.E. CE Florida CE
Speaker

Abstract

Neuroscience is experiencing an exciting era of integrating novel materials and tools to record neural activity made possible through significant advances in materials science, electrical engineering, and computer science. Certain technologies integrating these advances, such as Neuropixels, has exponentially moved forward our understanding of brain function in rodents and other model systems. However, even though current standards recording from human brain cells in vivo have provided incredible insight into how the human brain works in the past 30 years, the shift from lower spatial resolution (e.g. single channel, contact to contact spacing >150 µm) to higher spatial resolution technologies (contact to contact spacing <150 µm) in recording single cell activity has not been broadly adopted in the human recording studies. Reasons can include regulatory and safety concerns as well as questions of whether these advanced, high-resolution technologies can offer anything more than what has been working for many researchers and clinical teams for decades.  I will attempt to lay out a series of studies we performed at multiple institutes including MGH that may paint a picture of the type and kind of neural activity these new tools could provide even in the operating room setting ranging from basic science to clinically relevant studies. In addition, I will discuss some of the challenges we had in implementing, and translating, these technologies for use in humans as well as try to answer questions on what these tools can offer in advancing our understanding of human single neurons.

Learning Objectives:

1. Define the limitations and challenges in current clinical brain recording devices in characterizing human brain activity.

2. Identify various challenges in translating novel neural recording devices to recording from the human brain in the clinical domain.

3. Define the clinically and scientifically relevant advances in our knowledge of the brain afforded by bringing these technologies into the human brain recording domain.


Show Resources
You May Also Like
JUN 21, 2022 6:00 AM PDT
JUN 21, 2022 6:00 AM PDT
Date: June 21, 2022 Time: 6:00am (PDT), 9:00am (EDT), 3:00pm (CEST) The global understanding and practice of medicine is currently undergoing a revolutionary change. This shift to precision...
JUN 28, 2022 6:45 AM PDT
JUN 28, 2022 6:45 AM PDT
Date: June 28, 2022 Time: 3:00pm (BST), 4:00pm (CET), 9:00am (CST), 7am (PST) Light-sheet microscopy is an extremely versatile imaging technique with a vast range of implementations that are...
JUL 19, 2022 8:00 AM PDT
JUL 19, 2022 8:00 AM PDT
Date: July 19, 2022 Time: 8:00am (PDT), 11:00pm (EDT), 5:00pm (CEST) Traditional liver perfusion procedures are difficult to perform and require extensive training, steady hands, and long-st...
APR 28, 2022 8:00 AM PDT
APR 28, 2022 8:00 AM PDT
Date: April 28, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Human pluripotent stem cells (PSCs) and their derivatives hold great potentials in...
MAY 17, 2022 9:00 AM PDT
MAY 17, 2022 9:00 AM PDT
Date: May 17, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 8:00pm (CEST) Gene therapeutics have great potential to treat many severe diseases in an unprecedented, targeted manner. The biopharmace...
JUN 29, 2022 7:00 AM PDT
JUN 29, 2022 7:00 AM PDT
Date: June 29, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) Imaging live cells is key to reveal their inner workings, dynamics, and function. Current technological advances in confo...
Loading Comments...
Show Resources