NOV 21, 2019 9:00 AM PST

The role of immune cells and immune checkpoints in multiple myeloma

Speaker
  • PhD candidate, University Hospital Bonn, Germany
    Biography
      Nathalie is currently a PhD student at the Department for Oncology, Immunology and Hematology at the University Hospital Bonn in Germany.
      She is working in the biomedical research laboratory under the direction of Prof. Dr. Peter Brossart. Her thesis focuses on immunotherapy in multiple myeloma.
      Currently she investigates the regulation of immune cells and the expression of immune checkpoints e.g. by using CRISPR/Cas9 technology and flow cytometry.

      Nathalie accomplished her studies in biochemistry at the Heinrich-Heine University of Düsseldorf, Germany, in 2014. For her master thesis she went to the laboratory of Prof. Ruth J. Muschel at the University of Oxford, UK. There she studied the role of myeloid cells in liver metastasis e.g. by using immunohistochemistry and lentiviral transfections.

      While she is very passionate about basic cancer research, equally important to her is science communication and health education.

    Abstract
    DATE:  November 21, 2019
    TIME:   9:00am PST, 12:00pm EST
     
    Multiple Myeloma is a disease of terminally differentiated plasma cells with the massive production of monoclonal immunoglobulins in the bone marrow.

    Today there are many treatment modalities ongoing targeting the myeloma microenvironment, but especially immunotherapy seems to be a promising approach.

    Immune checkpoints are critical components in the regulation of immune cell responses. If immune cells are activated due to the contact to an antigen, they also need to be controlled to prevent an overactive immune response. These control checkpoints are often over-expressed in cancer cells and therefore protect them from the tumour-specific immune response enabling tumour immune escape.
    We investigate the role of the PD-1/PD-L1 immune checkpoint during myeloma disease progression and determine combinatorial approaches of immunotherapeutic drugs to increase myeloma cell killing efficiency.
     
    Learning Objectives:
    • Identify tumour immune microenvironment
    • Examine immunotherapeutic strategies for hematologic malignancies
    • Discuss flow cytometry to investigate immune cell regulation in multiple myeloma
     
    LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

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