OCT 28, 2021 6:00 AM PDT

Role of TrimericS IgG Antibodies in monitoring the immune response of recipients of COVID-19 Vaccination

Sponsored by: DiaSorin
C.E. Credits: P.A.C.E. CE Florida CE
Speaker

Abstract
Date:  October 28, 2021
Time: 6:00am (PDT),  09:00am (EDT)
 
COVID-19 has spurred the development of a plethora of tests from various manufacturers. While molecular tests and rapid antigen tests are targeted for early diagnosis, serology tests play a different and perhaps even larger role by supporting epidemiological studies, furthering the understanding of longitudinal immunity, and in assessing the efficacy of vaccine development. The efficient use of serology tests in understanding immunity, both in response to disease or vaccination, requires evaluation of any given assay’s diagnostic performance and discriminative ability. The spike protein has been the preferred antigen for use in vaccines, because most neutralizing antibodies are directed against this surface exposed protein on the virus that is essential for entry into human cells. Coronavirus spikes form large heavily glycosylated homo-trimeric complexes, yet due to their instability in vitro, monomeric presentations of the spike protein, including the receptor binding domain (RBD) only, have been most prevalently used in immunoassays. While the diagnostic performance of assays using RBD as an antigen have shown better results compared to spike and nucleoprotein antigens, the trimeric form was shown to be associated with greater sensitivity for the detection of SARS-CoV-2 IgG antibody in human samples. Here, the performance of the LIAISON® SARS-CoV-2 TrimericS IgG assay are described to evaluate the immune response in a population of HCWs naturally infected and after receving a complete vaccination program.
 
Learning Objectives
  • Evaluate the humoral response after administration of SARS-CoV-2 mRNA vaccine
  • To assess the performance of serology assay in post vaccination monitoring of fragile individuals
  • To evaluate the clinical impact of serology test in monitoring humoral response of fragile individuals
 
 
Webinars will be available for unlimited on-demand viewing after live event.
 
LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

Show Resources
You May Also Like
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
NOV 09, 2021 11:00 AM PST
C.E. CREDITS
NOV 09, 2021 11:00 AM PST
Date: November 09, 2021 Time: 11:00am (PDT), 02:00pm (EDT) Clinical translation of human pluripotent stem cells (hPSCs) requires advanced strategies that ensure safe and robust long-term gro...
JUN 17, 2021 11:00 AM PDT
C.E. CREDITS
JUN 17, 2021 11:00 AM PDT
Date: June 17, 2021 Time: 11:00am PDT, 8:00pm CET BACKGROUND Kidney transplant recipients and patients on hemodialysis are immunocompromised populations excluded from vaccine trials. Data ar...
NOV 17, 2021 8:00 AM PST
C.E. CREDITS
NOV 17, 2021 8:00 AM PST
Date: November 17, 2021 Time: 8:00am (PDT), 11:00am (EDT) From waste disposal to promising biomarkers and therapeutic agents, exosomes and other extracellular vesicles are valuable in resear...
OCT 20, 2021 10:00 AM PDT
C.E. CREDITS
OCT 20, 2021 10:00 AM PDT
Date: October 20, 2021 Time:10:00am (PDT), 1:00pm (EDT) As the prevalence of Diabetes continues to rise in many areas across the globe, healthcare providers continue to look for methods that...
Loading Comments...
Show Resources